Migalastat and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with migalastat.
Migalastat Food
Moderate Food Interaction
ADJUST DOSING INTERVAL: Food may reduce the oral bioavailability of migalastat. When migalastat was administered one hour before a high-fat (850 calories; 56% from fat) or light meal (507 calories; 30% from fat), or one hour after a light meal, mean migalastat peak plasma concentration (Cmax) decreased by 15% to 39% and systemic exposure (AUC) decreased by 37% to 42% compared to administration in the fasting state.
MANAGEMENT: Migalastat should be taken on an empty stomach. Patients should avoid eating for at least 2 hours before and 2 hours after taking migalastat to give a minimum 4 hours fast. Clear liquids can be consumed during this 4-hour period.
References (2)
- Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink
- (2018) "Product Information. Galafold (migalastat)." Amicus Therapeutics U.S., Inc.
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Migalastat drug interactions
There is 1 drug interaction with migalastat.
Migalastat disease interactions
There is 1 disease interaction with migalastat which include:
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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