Robinul Forte and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with Robinul Forte (glycopyrrolate).
glycopyrrolate Alcohol (Ethanol)
Moderate Drug Interaction
GENERALLY AVOID: Use of anticholinergic agents with alcohol may result in sufficient impairment of attention so as to render driving and operating machinery more hazardous. In addition, the potential for abuse may be increased with the combination. The mechanism of interaction is not established but may involve additive depressant effects on the central nervous system. No effect of oral propantheline or atropine on blood alcohol levels was observed in healthy volunteers when administered before ingestion of a standard ethanol load. However, one study found impairment of attention in subjects given atropine 0.5 mg or glycopyrrolate 1 mg in combination with alcohol.
MANAGEMENT: Alcohol should generally be avoided during therapy with anticholinergic agents. Patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them.
References
- Linnoila M "Drug effects on psychomotor skills related to driving: interaction of atropine, glycopyrrhonium and alcohol." Eur J Clin Pharmacol 6 (1973): 107-12
High Blood Pressure (Hypertension)
Minor Potential Hazard, Moderate plausibility
anticholinergics - hypertension
Cardiovascular effects of anticholinergics may exacerbate hypertension. Therapy with anticholinergic agents should be administered cautiously in patients with hypertension.
References
- "Product Information. Benadryl (diphenhydramine)." Parke-Davis PROD (2002):
- "Product Information. Antivert (meclizine)." Roerig Division PROD (2001):
- "Product Information. Marezine (cyclizine)." Glaxo Wellcome PROD (2001):
- Valentin N, Staffeldt H, Kyst A "Effect of i.v. atropine on cardiac rhythm, heart rate, blood pressure and airway secretion during isoflurane anaesthesia." Acta Anaesthesiol Scand 28 (1984): 621-4
- "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics (2022):
- "Product Information. Artane (trihexyphenidyl)." Lederle Laboratories PROD (2001):
- "Product Information. Atropisol (atropine ophthalmic)." Ciba Vision Ophthalmics (2002):
Robinul Forte drug interactions
There are 202 drug interactions with Robinul Forte (glycopyrrolate).
Robinul Forte disease interactions
There are 15 disease interactions with Robinul Forte (glycopyrrolate) which include:
- arrhythmias
- autonomic neuropathy
- GI obstruction
- glaucoma
- obstructive uropathy
- tardive dyskinesia
- infectious diarrhea
- myasthenia gravis
- ulcerative colitis
- psychoses
- Down's syndrome
- liver impairment
- renal impairment
- hypertension
- fever
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.