Antizol and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Antizol (fomepizole).
Alcohol (Ethanol) Fomepizole
Major Drug Interaction
GENERALLY AVOID: The manufacturer reports that oral doses of fomepizole (10 to 20 mg/kg) will significantly reduce the rate of elimination of moderate doses of ethanol by approximately 40% when given to healthy volunteers. The mechanism is via alcohol dehydrogenase inhibition. By a similar mechanism, ethanol will decrease the rate of elimination of fomepizole.
MANAGEMENT: In general, ethanol and fomepizole should not be coadministered in the treatment of ethylene glycol poisoning.
References (1)
- (2001) "Product Information. Antizol (fomepizole)." Jazz Pharmaceuticals
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Antizol drug interactions
There is 1 drug interaction with Antizol (fomepizole).
Antizol disease interactions
There is 1 disease interaction with Antizol (fomepizole) which include:
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- Drug class: antidotes
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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