Bedaquiline and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with bedaquiline.
Bedaquiline Food
Moderate Food Interaction
ADJUST DOSING INTERVAL: Food enhances the oral bioavailability of bedaquiline. When administered with a standard meal containing approximately 22 grams of fat (558 total Kcal), the relative bioavailability of bedaquiline increased by approximately 2-fold compared to administration under fasted conditions.
GENERALLY AVOID: Coadministration with alcohol may increase the risk of hepatotoxicity associated with the use of bedaquiline. In clinical trials, hepatic adverse drug reactions developed in more bedaquiline-treated patients than in those who received other drugs used to treat tuberculosis. In patients receiving bedaquiline or placebo in combination with other drugs used to treat multidrug-resistant tuberculosis, reversible aminotransferase elevations of at least 3 times the upper limit of normal developed more frequently in the bedaquiline treatment group [10.8%] than in the placebo group [5.7%].
MANAGEMENT: To ensure maximal oral absorption, bedaquiline should be taken with food. Patients should avoid alcohol use during treatment.
References (1)
- (2013) "Product Information. Sirturo (bedaquiline)." Janssen Pharmaceuticals
Switch to consumer interaction data
Bedaquiline drug interactions
There are 599 drug interactions with bedaquiline.
Bedaquiline disease interactions
There are 5 disease interactions with bedaquiline which include:
Report options
More about bedaquiline
- bedaquiline consumer information
- Check interactions
- Compare alternatives
- Side effects
- Dosage information
- During pregnancy
- Drug class: diarylquinolines
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Aminosalicylic acid
Aminosalicylic acid systemic is used for tuberculosis, active, tuberculosis, resistant
Sirturo
Sirturo (bedaquiline) is an oral antimycobacterial treatment that may be used as a part of ...
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.