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Diarylquinolines

What are Diarylquinolines?

Diarylquinolines are antimycobacterial drugs that interfere with mycobacterial energy production by binding and inhibiting subunit c of ATP synthase in the mycobacterium. The mycobactericidal activity is due to it being unable to generate energy. Diarylquinolines are used as part of combination therapy in pulmonary multi-drug resistant tuberculosis (MDR-TB) and usually administered as directly observed therapy (DOT).

List of Diarylquinolines:

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Sirturo (Pro)
generic name: bedaquiline
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Further information

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Medical conditions associated with diarylquinolines:

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