Aminophylline/ephedrine/phenobarbital/potassium iodide and Alcohol/Food Interactions
There are 9 alcohol/food/lifestyle interactions with aminophylline / ephedrine / phenobarbital / potassium iodide.
Phenobarbital Caffeine
Moderate Drug Interaction
Using PHENobarbital together with aminophylline may decrease the effects of aminophylline. Contact your doctor if your condition changes or if you experience breathing difficulties. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Ephedrine Caffeine
Moderate Drug Interaction
Both ePHEDrine and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Aminophylline Caffeine
Moderate Drug Interaction
Both aminophylline and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Ephedrine Caffeine
Minor Drug Interaction
Information for this minor interaction is available on the professional version.
Phenobarbital Alcohol (Ethanol)
Major Drug Interaction
Ask your doctor before using PHENobarbital together with ethanol, this can add to dizziness, drowsiness and other side effects of PHENobarbital. Be careful if you drive or do activities that require you to be awake and alert. Talk with your doctor before using any medications together, or drinking alcohol with PHENobarbital. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Phenobarbital Alcohol (Ethanol)
Moderate Drug Interaction
Using PHENobarbital together with aminophylline may decrease the effects of aminophylline. Contact your doctor if your condition changes or if you experience breathing difficulties. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Ephedrine Alcohol (Ethanol)
Minor Drug Interaction
Information for this minor interaction is available on the professional version.
Phenobarbital High Blood Pressure (Hypertension)
Major Potential Hazard, Moderate plausibility
barbiturates IV - cardiovascular
The intravenous administration of barbiturates may produce severe cardiovascular reactions such as bradycardia, hypertension, or vasodilation with fall in blood pressure, particularly during rapid infusion. Parenteral therapy with barbiturates should be administered cautiously in patients with hypertension, hypotension, or cardiac disease. The intravenous administration of barbiturates should be reserved for emergency treatment of acute seizures or for anesthesia.
References
- (2001) "Product Information. Phenobarbital (phenobarbital)." Lilly, Eli and Company
- American Medical Association, Division of Drugs and Toxicology (1994) "Drug evaluations annual 1994." Chicago, IL: American Medical Association;
- (2001) "Product Information. Amytal Sodium (amobarbital)." Lilly, Eli and Company
- (2001) "Product Information. Nembutal Sodium (pentobarbital)." Abbott Pharmaceutical
- (2001) "Product Information. Seconal Sodium (secobarbital)." Lilly, Eli and Company
Aminophylline High Blood Pressure (Hypertension)
Moderate Potential Hazard, Moderate plausibility
methylxanthines - tachyarrhythmias
The use of theophyllines is associated with an increase in heart rate which may progress to supraventricular tachycardia or ventricular arrhythmia at high serum drug concentrations. Appearance of cardiac adverse effects is generally an indication of theophylline toxicity, although patients with a history of tachyarrhythmias may be more susceptible to the chronotropic effect of these drugs. Therapy with theophyllines should be administered cautiously in such patients. Caution is also advised in patients with hypertension, hyperthyroidism, angina pectoris, or recent myocardial infarction, since high dosages of the drugs are associated with positive inotropic as well as chronotropic effects. Clinical monitoring of serum drug concentrations is recommended to prevent toxicity.
References
- Hendeles L, Weinberger M, Johnson G (1978) "Monitoring serum theophylline levels." Clin Pharmacokinet, 3, p. 294-312
- Sessler CN (1990) "Theophylline toxicity: clinical features of 116 consecutive cases." Am J Med, 88, p. 567-76
- Schiff GD, Hegde HK, LaCloche L, Hryhorczuk DO (1991) "Inpatient theophylline toxicity: preventable factors." Ann Intern Med, 114, p. 748-53
- Marchlinski FE, Miller JM (1985) "Atrial arrhythmias exacerbated by theophylline: response to verapamil and evidence for triggered activity in man." Chest, 88, p. 931-4
- Levine JH, Michael JR, Guarnieri T (1985) "Multifocal atrial tachycardia: a toxic effect of theophylline." Lancet, 1, p. 12-4
- Taniguchi A, Ohe T, Shimorura K (1989) "Theophylline-induced ventricular tachycardia in a patient with chronic lung disease: sensitivity to verapamil." Chest, 96, p. 958-9
- Bittar G, Friedman HS (1991) "The arrhythmogenicity of theophylline: a multivariate analysis of clinical determinants." Chest, 99, p. 1415-20
- Patel AK, Skatrud JB, Thomsen JH (1981) "Cardiac arrhythmias due to oral aminophylline in patients with chronic obstructive pulmonary disease." Chest, 80, p. 661-5
- Albert S (1987) "Aminophylline toxicity." Pediatr Clin North Am, 34, p. 61-73
- Milgrom H, Bender B (1993) "Current issues in the use of theophylline." Am Rev Respir Dis, 147, s33-9
- Chazan R, Karwat K, Tyminska K, Tadeusiak W, Droszcz W (1995) "Cardiac arrhythmias as a result of intravenous infusions of theophylline in patients with airway obstruction." Int J Clin Pharmacol Ther, 33, p. 170-5
- Mccarthy M (1997) "Theophylline, beta-agonists, and cardiovascular death." Lancet, 349, p. 33
Aminophylline/ephedrine/phenobarbital/potassium iodide drug interactions
There are 983 drug interactions with aminophylline / ephedrine / phenobarbital / potassium iodide.
Aminophylline/ephedrine/phenobarbital/potassium iodide disease interactions
There are 31 disease interactions with aminophylline / ephedrine / phenobarbital / potassium iodide which include:
- acute alcohol intoxication
- drug dependence
- liver disease
- porphyria
- rash
- respiratory depression
- cardiovascular
- prolonged hypotension
- renal dysfunction
- PUD
- renal dysfunction
- seizure disorders
- cardiovascular disease
- suicidal tendency
- adrenal insufficiency
- depression
- hematologic toxicity
- osteomalacia
- paradoxical reactions
- BPH
- diabetes
- hyperthyroidism
- GERD
- hemodialysis
- reduced clearance
- tachyarrhythmias
- heart disease
- dermatitis herpetiformis
- vasculitis
- BPH
- diabetes
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.