Acetaminophen / aspirin / phenylpropanolamine and Alcohol / Food Interactions
There are 2 alcohol/food/lifestyle interactions with acetaminophen / aspirin / phenylpropanolamine which include:
aspirin ↔ Caffeine
Minor Drug Interaction
Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
For clinical details see professional interaction data.
phenylpropanolamine ↔ food
Moderate Food Interaction
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Alcohol may potentiate the central nervous system and cardiovascular effects of centrally-acting appetite suppressants. In one study, concurrent administration of methamphetamine (30 mg intravenously) and ethanol (1 gm/kg orally over 30 minutes) increased heart rate by 24 beats/minute compared to methamphetamine alone. This increases cardiac work and myocardial oxygen consumption, which may lead to more adverse cardiovascular effects than either agent alone. Subjective effects of ethanol were diminished in the eight study subjects, but those of methamphetamine were not affected. The pharmacokinetics of methamphetamine were also unaffected except for a decrease in the apparent volume of distribution at steady state.
MANAGEMENT: Concomitant use of centrally-acting appetite suppressants and alcohol should be avoided if possible, especially in patients with a history of cardiovascular disease. Patients should be counselled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
- Mendelson J, Jones RT, Upton R, Jacob P 3rd "Methamphetamine and ethanol interactions in humans." Clin Pharmacol Ther 57 (1995): 559-68
- "Product Information. Didrex (benzphetamine)" Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Suprenza (phentermine)." Akrimax Pharmaceuticals, Cranford, NJ.
acetaminophen / aspirin / phenylpropanolamine drug Interactions
There are 1003 drug interactions with acetaminophen / aspirin / phenylpropanolamine
acetaminophen / aspirin / phenylpropanolamine disease Interactions
There are 17 disease interactions with acetaminophen / aspirin / phenylpropanolamine which include:
- Liver Disease
- Gi Toxicity
- Renal Dysfunction
- Reye's Syndrome
- Cardiovascular Disease
- G-6-Pd Deficiency
Drug Interaction Classification
Do not stop taking any medications without consulting your healthcare provider.