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Drug Interactions between Sutent and vorinostat

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

No interactions were found between Sutent and vorinostat. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Sutent

A total of 439 drugs are known to interact with Sutent.

vorinostat

A total of 69 drugs are known to interact with vorinostat.

Drug and food interactions

Moderate

SUNItinib food

Applies to: Sutent (sunitinib)

GENERALLY AVOID: Consumption of grapefruit or grapefruit juice during sunitinib therapy may increase the plasma concentrations of sunitinib. The proposed mechanism is inhibition of CYP450 3A4-mediated metabolism by certain compounds present in grapefruit.

MANAGEMENT: Although clinical data are lacking, it may be advisable to avoid the consumption of large amounts of grapefruit or grapefruit juice during sunitinib therapy.

References

  1. "Product Information. Sutent (sunitinib)." Pfizer U.S. Pharmaceuticals Group (2006):

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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