Can you take Nitroprusside with Sepiapterin?
1 drug interaction and 13 additional warnings found for the following 2 drugs:
- nitroprusside
- sepiapterin
Drug interactions
Moderate drug interactions
Moderate:
sodium nitroprusside sepiapterin
Applies to: nitroprusside and sepiapterin
Using sepiapterin together with sodium nitroprusside may lower your blood pressure and increase the risk of:
- dizziness
- weakness
- headache
- flushing
- fainting
These side effects are most likely to be seen at the beginning of treatment with sepiapterin, following a dose increase, or when treatment is restarted after an interruption.
Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome.
Avoid driving or operating hazardous machinery until you know how the medication affects you, and use caution when getting up from a sitting or lying position.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
sepiapterin Food/Lifestyle
Applies to: sepiapterin
Food helps to increase the absorption of sepiapterin.
To ensure adequate blood levels, sepiapterin should be given with food. Additional food should be also consumed after the dose of sepiapterin is taken.
Moderate:
sodium nitroprusside Alcohol (Ethanol)
Applies to: nitroprusside
Ethanol and sodium nitroprusside may have additive effects in lowering your blood pressure.
You may experience headache, dizziness, lightheadedness, fainting, or changes in pulse or heart rate, especially when treatment is started, the dose is changed, or treatment is restarted.
Tell your doctor promptly if these symptoms occur and seek urgent medical help if you faint or have severe dizziness.
Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
11 potential interactions Applies to: 10 conditions, including Anemia, Peripheral Arterial Disease, Pseudotumor Cerebri, Liver Disease, and Sepsis.
Anemia
Moderate:
nitroprusside
The sodium nitroprusside in nitroprusside has a moderate potential interaction with Anemia.
When sodium nitroprusside is used to control hypotension during anesthesia, the patient's capacity to compensate for anemia and hypovolemia may be diminished. If possible, preexisting anemia and hypovolemia should be corrected prior to administration of sodium nitroprusside.
Aortic Coarctation
Major:
nitroprusside
The sodium nitroprusside in nitroprusside has a major potential interaction with Aortic Coarctation.
Nitroprusside should not be used for the treatment of compensatory hypertension, such as that associated with aortic coarctation or arteriovenous shunt.
Arteriovenous Shunting
Major:
nitroprusside
The sodium nitroprusside in nitroprusside has a major potential interaction with Arteriovenous Shunting.
Nitroprusside should not be used for the treatment of compensatory hypertension, such as that associated with aortic coarctation or arteriovenous shunt.
Cerebral Vascular Disorder
Major:
nitroprusside
The sodium nitroprusside in nitroprusside has a major potential interaction with Cerebral Vascular Disorder.
The use of nitroprusside is contraindicated in patients with cerebral vascular insufficiency.
Leber's Disease
Major:
nitroprusside
The sodium nitroprusside in nitroprusside has a major potential interaction with Leber's Disease.
The use of nitroprusside is contraindicated in patients with defective or absent rhodanase activity, such as patients with congenital (Leber's) optic atrophy or with tobacco amblyopia.
Liver Disease
Moderate:
nitroprusside
The sodium nitroprusside in nitroprusside has a moderate potential interaction with Liver Disease.
Use caution when administering sodium nitroprusside to patients with hepatic insufficiency.
Moderate:
sepiapterin
Sepiapterin has a moderate potential interaction with Liver Disease.
The effect of renal or liver dysfunction on the pharmacokinetics of sepiapterin or the active metabolite tetrahydrobiopterin (BH4) is unknown.
Peripheral Arterial Disease
Major:
nitroprusside
The sodium nitroprusside in nitroprusside has a major potential interaction with Peripheral Arterial Disease.
Sodium nitroprusside should not be used for the treatment of acute congestive heart failure associated with reduced peripheral vascular resistance such as high- output heart failure that may be seen in endotoxic sepsis.
Pseudotumor Cerebri
Moderate:
nitroprusside
The sodium nitroprusside in nitroprusside has a moderate potential interaction with Pseudotumor Cerebri.
Like other vasodilators, sodium nitroprusside can cause increases in intracranial pressure. In patients whose intracranial pressure is already elevated, sodium nitroprusside should be used only with extreme caution.
Renal Dysfunction
Moderate:
sepiapterin
Sepiapterin has a moderate potential interaction with Renal Dysfunction.
The effect of renal or liver dysfunction on the pharmacokinetics of sepiapterin or the active metabolite tetrahydrobiopterin (BH4) is unknown.
Sepsis
Major:
nitroprusside
The sodium nitroprusside in nitroprusside has a major potential interaction with Sepsis.
Sodium nitroprusside should not be used for the treatment of acute congestive heart failure associated with reduced peripheral vascular resistance such as high- output heart failure that may be seen in endotoxic sepsis.
Report options
More resources
nitroprusside
A total of 251 drugs are known to interact with nitroprusside.
- Nitroprusside is in the following drug classes: agents for hypertensive emergencies, vasodilators.
- Nitroprusside is used to treat the following conditions:
sepiapterin
A total of 38 drugs are known to interact with sepiapterin.
- Sepiapterin is in the drug class miscellaneous metabolic agents.
- Sepiapterin is used to treat Phenylketonuria.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.