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Drug Interactions between mexiletine and Olysio

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

mexiletine simeprevir

Applies to: mexiletine and Olysio (simeprevir)

MONITOR: Coadministration with simeprevir may increase the plasma concentrations of certain antiarrhythmic agents that are metabolized by CYP450 1A2 or 3A4 such as amiodarone, disopyramide, flecainide, mexiletine, propafenone, and quinidine. In vivo, simeprevir mildly inhibits CYP450 1A2 and intestinal CYP450 3A4, but does not affect hepatic CYP450 3A4 activity. Serious and/or life-threatening reactions including cardiac arrhythmias like torsade de pointes may occur if antiarrhythmic drug levels are significantly increased.

MANAGEMENT: Caution is advised if simeprevir is prescribed in combination with antiarrhythmic agents that are metabolized by CYP450 1A2 or 3A4. Pharmacologic response and plasma antiarrhythmic drug levels should be monitored more closely whenever simeprevir is added to or withdrawn from therapy, and the antiarrhythmic dosage adjusted as necessary.

References (1)
  1. (2013) "Product Information. Olysio (simeprevir)." Janssen Pharmaceuticals

Drug and food interactions

Moderate

simeprevir food

Applies to: Olysio (simeprevir)

ADJUST DOSING INTERVAL: Food significantly enhances the oral bioavailability of simeprevir, although the type of food does not seem to matter. In healthy study subjects, administration of simeprevir after a high-fat, high-caloric (928 kcal) breakfast increased systemic exposure (AUC) by 61% and delayed absorption by 1 hour, while administration after a normal caloric (533 kcal) breakfast increased AUC by 69% and delayed absorption by 1.5 hours.

MANAGEMENT: To ensure maximal oral absorption, simeprevir should be administered with food.

References (1)
  1. (2013) "Product Information. Olysio (simeprevir)." Janssen Pharmaceuticals

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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