Can you take Magnesium hydroxide with Polysaccharide Iron?
1 drug interaction and 9 additional warnings found for the following 2 drugs:
- magnesium hydroxide
- Polysaccharide Iron (iron polysaccharide)
Drug interactions
Moderate drug interactions
Moderate:
magnesium hydroxide iron polysaccharide
Applies to: magnesium hydroxide and Polysaccharide Iron (iron polysaccharide)
By reducing the acidity level in the stomach, medications like magnesium hydroxide may interfere with the absorption of iron polysaccharide into the bloodstream and reduce its effectiveness.
If you require treatment with both medications, it is recommended that you take iron polysaccharide at least 2 hours before or 2 hours after magnesium hydroxide to help minimize the impact of the interaction.
Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
iron polysaccharide Food/Lifestyle
Applies to: Polysaccharide Iron (iron polysaccharide)
Food may reduce the absorption and blood levels of iron polysaccharide. In addition, some oral medications can also interfere with iron polysaccharide absorption into the bloodstream, which may make the medication less effective in treating your condition. Likewise, iron polysaccharide may interfere with the absorption of other orally administered medications.
You should take iron polysaccharide on an empty stomach at least one hour before or two hours after a meal.
Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications.
Talk to your doctor or pharmacist if you have questions about how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
8 potential interactions Applies to: 8 conditions, including Inflammatory Bowel Disease, Peptic Ulcer, Noninfectious Colitis, Renal Dysfunction, and Blood Transfusion.
Achlorhydria
Moderate:
Polysaccharide Iron
The iron polysaccharide in Polysaccharide Iron has a moderate potential interaction with Achlorhydria.
Gastric acidity increases iron bioavailability by maintaining the ingested iron in a reduced form as ferrous ions, which are more readily absorbed than ferric ions. Therefore, when iron therapy is administered orally, higher dosages may be necessary for patients with decreased gastric acid production. Also, a liquid formulation is recommended in these patients because dissolution of the tablet coating depends on normal gastric acidity.
Blood Transfusion
Major:
Polysaccharide Iron
The iron polysaccharide in Polysaccharide Iron has a major potential interaction with Blood Transfusion.
There is no excretory mechanism for iron. Iron will correct only hemoglobin abnormalities due to iron deficiency and should not be used to treat conditions such as thalassemia, hemosiderosis, hemochromatosis, normocytic anemia (unless iron deficiency exists), or in patients receiving blood transfusions. Clinical monitoring of erythropoietic function and ferritin levels is recommended.
Gastrointestinal Obstruction
Major:
magnesium hydroxide
Magnesium hydroxide has a major potential interaction with Gastrointestinal Obstruction.
The use of laxatives is contraindicated in patients with intestinal obstruction disorders. Patients with intestinal obstruction disorders may need their underlying condition treated to correct the constipation. Some laxatives require reduction in the colon to their active form to be effective which may be a problem in patients with intestinal obstruction.
Hemoglobinopathy
Major:
Polysaccharide Iron
The iron polysaccharide in Polysaccharide Iron has a major potential interaction with Hemoglobinopathy.
There is no excretory mechanism for iron. Iron will correct only hemoglobin abnormalities due to iron deficiency and should not be used to treat conditions such as thalassemia, hemosiderosis, hemochromatosis, normocytic anemia (unless iron deficiency exists), or in patients receiving blood transfusions. Clinical monitoring of erythropoietic function and ferritin levels is recommended.
Inflammatory Bowel Disease
Major:
magnesium hydroxide
Magnesium hydroxide has a major potential interaction with Inflammatory Bowel Disease.
The use of laxatives is contraindicated in patients with inflammatory bowel disease. Patients with inflammatory bowel disease may experience colonic perforation with use of stimulant laxatives.
Noninfectious Colitis
Moderate:
Polysaccharide Iron
The iron polysaccharide in Polysaccharide Iron has a moderate potential interaction with Noninfectious Colitis.
Iron can be irritating and damaging to gastrointestinal mucosa. Iron therapy should be administered cautiously in patients with peptic ulcer disease, enteritis, or ulcerative colitis.
Peptic Ulcer
Moderate:
Polysaccharide Iron
The iron polysaccharide in Polysaccharide Iron has a moderate potential interaction with Peptic Ulcer.
Iron can be irritating and damaging to gastrointestinal mucosa. Iron therapy should be administered cautiously in patients with peptic ulcer disease, enteritis, or ulcerative colitis.
Renal Dysfunction
Major:
magnesium hydroxide
Magnesium hydroxide has a major potential interaction with Renal Dysfunction.
Magnesium is eliminated by the kidney. The serum concentration of magnesium is increased in patients with renal impairment. Magnesium toxicity includes CNS depression, muscular paralysis, respiratory depression, hypotension and prolonged cardiac conduction time. Disappearance of the patellar reflex is a useful clinical sign of magnesium intoxication. Therapy with magnesium should be administered cautiously and dosages should be modified in patients with compromised renal function. Clinical monitoring of serum magnesium levels is recommended.
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More resources
magnesium hydroxide
A total of 440 drugs are known to interact with magnesium hydroxide.
- Magnesium hydroxide is in the following drug classes: antacids, laxatives.
-
Magnesium hydroxide is used to treat the following conditions:
- Acne (off-label)
- Constipation
- Indigestion
Polysaccharide Iron
A total of 89 drugs are known to interact with Polysaccharide Iron.
- Polysaccharide iron is in the drug class iron products.
- Polysaccharide iron is used to treat Iron Deficiency Anemia.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.