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Letermovir Drug Interactions

A total of 485 drugs are known to interact with letermovir.

  • 96 major drug interactions
  • 368 moderate drug interactions
  • 21 minor drug interactions

Check for interactions with letermovir

Type in a drug name and select a drug from the list.

Medications known to interact with letermovir

A B C D E F G H I K L M N O P Q R S T V W Z

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  • efavirenz (Sustiva)
  • efavirenz / emtricitabine / tenofovir (Atripla)
  • efavirenz / lamivudine / tenofovir (Symfi, Symfi Lo)
  • elbasvir / grazoprevir (Zepatier)
  • eletriptan (Relpax)
  • eliglustat (Cerdelga)
  • emtricitabine / lopinavir / ritonavir / tenofovir (AccessPak for HIV PEP Expanded with Kaletra)
  • enalapril / felodipine (Lexxel)
  • enzalutamide (Xtandi)
  • ephedrine / phenobarbital / potassium iodide / theophylline (Quadrinal)
  • ephedrine / phenobarbital / theophylline (Tedrigen, Theodrine)
  • eplerenone (Inspra)
  • ergonovine (Ergotrate, Ergotrate Maleate)
  • ergotamine (Ergomar)
  • erlotinib (Tarceva)
  • erythromycin (Erythrocin, EryPed, E-Mycin, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, Ilosone, Robimycin, PCE Dispertab, Wyamycin S, E.E.S. Granules, E.E.S.-200, E.E.S.-400, E.E.S.-400 Filmtab, Erythrocot, Eryc, MY-E)
  • erythromycin / sulfisoxazole (Pediazole, Eryzole, Sulfimycin, E S P)
  • escitalopram (Lexapro)
  • esomeprazole (Nexium, Nexium 24HR, Nexium IV)
  • esomeprazole / naproxen (Vimovo)
  • estazolam (Prosom)
  • esterified estrogens (Menest, Estratab)
  • esterified estrogens / methyltestosterone (Estratest, EEMT, Estratest H.S., Covaryx, Syntest DS, EEMT HS, Menogen HS, Menogen, Syntest HS, Essian, Essian H.S., Covaryx HS, EEMT DS)
  • estradiol (Estrace, Estradiol Patch, Climara, Estrogel, Minivelle, Vivelle-Dot, Divigel, Femring, Vivelle, Estrogen Patches, Progynova, Estraderm, Evamist, Depo-Estradiol, Delestrogen, Depogen, Alora, Estradot, Dioval 40, Estragyn LA 5, Fematrix, Oestrodose, Gynogen LA 20, Dioval XX, Evorel, Aerodiol, Elleste Solo, Estrofem, Climodien, Delidose, Estradiol G GAM, Estreva, Oestrogel, Provames, Estra Pellets, Femtrace, Valergen, Dep Gynogen, Duragen, Estra-C, Estra-V 40, Estro-Cyp, Gynodiol, Estro-Span 40, Medidiol 10, Dura-Estrin, Fempatch, Esclim, Oesclim, Clinagen LA 40, Estro-LA, Menaval-20, Estradot 37.5, Estradot 50, Estradot 75, Estradot 100, Oestrogel Pump-Pack, Dermestril, FemSeven, Progynova TS, Sandrena, Zumenon, Adgyn Estro, FemSeven Sequi Phase I, Menorest Patch, Nuvelle TS Phase I, Climaval, FemTab, Estrasorb, Femtran, Primogyn Depot, Organon Oestradiol, Bedol, Oestradiol Implants, Dermestril Septem, Estrapatch, Femsept, Menorest, Oromone, Systen, Thais, Thaissept, Elestrin, Menostar)
  • estradiol topical (Vagifem, Estrace Vaginal Cream, Yuvafem, Estring, Imvexxy)
  • estradiol / levonorgestrel (Climara Pro)
  • estradiol / medroxyprogesterone (Lunelle)
  • estradiol / norethindrone (Activella, CombiPatch, Lopreeza, Amabelz, Mimvey, Mimvey Lo, Ena)
  • estradiol / norethindrone topical
  • estradiol / norgestimate (Ortho-Prefest, Prefest)
  • estradiol / progesterone (Bijuva)
  • estradiol / testosterone (Depo-Testadiol, Depotestogen, Dep Androgyn, Delatestadiol, Estra-Testrin, Valertest No 1, Duo-Cyp, Dura-Dumone, Duratestrin)
  • estrone (Aquest, Estrone AQ, Kestrone 5, Estragyn 5, Estro-A)
  • estropipate (Ogen, Ortho-Est, Ogen 0.625, Ogen 1.25, Ogen 2.5)
  • estropipate topical (Ogen Vaginal Cream)
  • eszopiclone (Lunesta)
  • ethinyl estradiol (Estinyl)
  • ethinyl estradiol / ethynodiol (Kelnor 1/35, Zovia 1/35E, Demulen, Demulen 1/35, Demulen 1/50, Kelnor 1/50, Zovia 1/50E, Malmorede)
  • ethinyl estradiol / etonogestrel (NuvaRing)
  • ethinyl estradiol / folic acid / levonorgestrel (FaLessa Kit)
  • ethinyl estradiol / levonorgestrel (Alesse, Aviane, Levora, Seasonique, Lutera, Aubra, Portia, Vienva, Ashlyna, Lessina, Jolessa, Camrese, Larissia, Kurvelo, Altavera, Levlen, Amethyst, Introvale, Amethia, Daysee, Sronyx, Chateal, Lillow, Falmina, Seasonale, Quasense, Orsythia, Balcoltra, Trivora, Levlite, Triphasil, Marlissa, Quartette, Fayosim, LoSeasonique, Nordette, Amethia Lo, Levonest, Nordette-21, Alesse-28, CamreseLo, Lybrel, Setlakin, Ayuna, Enpresse, Delyla, Aubra EQ, Chateal EQ, Rivelsa, Simpesse, Lo Simpesse, Cerinta, Jaimiess, Afirmelle, Elifemme, Nordette-28, Tri-Levlen, Triphasil-21, Triphasil-28, Alesse-21, Preven EC, Triquilar 21, Triquilar 28, Min-Ovral 21, Min-Ovral 28, Myzilra, Iclevia)
  • ethinyl estradiol / norelgestromin (Xulane, Ortho Evra)
  • ethinyl estradiol / norethindrone (Lo Loestrin Fe, Taytulla, Junel Fe 1/20, Microgestin Fe 1/20, Loestrin 24 Fe, Necon 1/35, Minastrin 24 Fe, Loestrin Fe 1.5/30, Mibelas 24 Fe, Junel Fe 1.5/30, Blisovi Fe 1.5/30, Loestrin 21 1/20, Nortrel 1/35, Jinteli, Microgestin 1.5/30, Blisovi 24 Fe, Blisovi Fe 1/20, Loestrin Fe 1/20, femhrt, Junel 1/20, Larin Fe 1.5/30, Cyclafem 1/35, Estrostep Fe, Balziva, Alyacen 1/35, Larin Fe 1/20, Junel Fe 24, Ortho-Novum 7/7/7, Ortho-Novum 1/35, Tarina Fe 1/20, Microgestin Fe 1.5/30, Fyavolv, Dasetta, Generess Fe, Wera, Wymzya Fe, Brevicon, Norinyl 1+35, Aranelle, Microgestin 1/20, Kaitlib Fe, Gildagia, Philith, Melodetta 24 Fe, Layolis Fe, Pirmella 7/7/7, Pirmella 1/35, Modicon, Cyclafem 7/7/7, Gildess Fe 1/20, Loestrin 21 1.5/30, Necon 0.5/35, Tri-Norinyl, Ovcon 50, Nortrel 7/7/7, Necon 7/7/7, Leena, Junel 1.5/30, Zenchent Fe, Nortrel 0.5/35, Aurovela Fe 1/20, Tri-Legest Fe, Tilia Fe, Lomedia 24 Fe, Dasetta 7/7/7, Dasetta 1/35, Zeosa, Hailey 1.5/30, Microgestin 24 Fe, Vyfemla, Gildess 24 Fe, Larin 24 Fe, Jevantique, Hailey Fe 1/20, Hailey 24 Fe, Ovcon 35, Genora 0.5/35, Nelova 0.5/35, Gildess Fe 1.5/30, Genora 1/35, Norethin 1/35 E, Nelova 10/11, Nelova 1/35, Necon 10/11, Jenest, Ortho-Novum 10/11, Ovcon 35 Fe, Femcon Fe, Nylia 7/7/7, Zenchent, Cyonanz, Nylia 1/35, Aurovela Fe 1.5/30, Aurovela 24 Fe, Aurovela 1/20, Leribane, Aurovela 1.5/30, Cyclafem 0.5/35, Tri-Legest, Lo Minastrin Fe, Briellyn, Hailey Fe 1.5/30, Nexesta Fe, Alyacen 7/7/7, Gildess 1.5/30, Gildess 1/20, Larin 1.5/30, Larin 1/20, Jevantique Lo)
  • ethinyl estradiol / norgestimate (Sprintec, Ortho Tri-Cyclen, TriNessa, Tri-Sprintec, Estarylla, Mononessa, Ortho Cyclen, Ortho Tri-Cyclen Lo, Mono-Linyah, Tri-Lo-Marzia, Previfem, TriNessa Lo, Femynor, Tri-Lo-Sprintec, Tri-Lo-Estarylla, Tri-Linyah, Mili, VyLibra, Tri-Estarylla, Tri-VyLibra, Tri Femynor, Tri-Previfem, Tri-Lo-Mili, Tri-Mili)
  • ethinyl estradiol / norgestrel (Cryselle, Lo/Ovral, Low-Ogestrel-28, Ovral, Lo/Ovral-28, Ovral-21, Elinest, Ogestrel 0.5/50, Ovral-28)
  • ethinyl estradiol / segesterone (Annovera)
  • ethosuximide (Zarontin)
  • etonogestrel (Nexplanon, Implanon)
  • etoposide (VePesid, Etopophos, Toposar)
  • everolimus (Afinitor, Zortress, Afinitor Disperz)
  • ezetimibe / simvastatin (Vytorin)
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  • lansoprazole / naproxen (Prevacid NapraPAC 500, Prevacid NapraPAC, Prevacid NapraPAC 375)
  • lapatinib (Tykerb)
  • larotrectinib (Vitrakvi)
  • lesinurad (Zurampic)
  • letrozole (Femara)
  • letrozole / ribociclib (Kisqali Femara Co-Pack)
  • leuprolide / norethindrone (Lupaneta Pack)
  • levobupivacaine (Chirocaine)
  • levomethadyl acetate (Orlaam)
  • levonorgestrel (Mirena, Plan B, Kyleena, Plan B One-Step, Skyla, Liletta, Aftera, Norplant System, Take Action, My Way, EContra One-Step, Morning After, Next Choice, New Day, Preventeza, React, EContra EZ, Opcicon One-Step, Her Style, Option 2, Athentia Next, AfterPill, My Choice, Next Choice One Dose, Fallback Solo)
  • lomitapide (Juxtapid)
  • lopinavir / ritonavir (Kaletra)
  • loratadine (Claritin, Alavert, Claritin 24 Hour Allergy, Allergy Relief Tablets, Claritin Reditabs, Wal-itin, Loratadine Reditab, Children's Claritin Allergy, Allergy Relief 24 Hour, Children's Allergy Relief 24 Hour, Vicks QlearQuil All Day & All Night 24 Hour Allergy Relief, Help I Have Allergies, ohm Allergy Relief, Clear-Atadine, Claritin Hives Relief, Dimetapp Children's ND Non-Drowsy Allergy, Clear-Atadine Children's, Bactimicina Allergy, Tavist ND)
  • loratadine / pseudoephedrine (Claritin-D, Loratadine-D 24 Hour, Claritin-D 24 Hour, Loratadine-D 12 Hour, AllerClear D-24 Hour, Alavert D-12 Hour Allergy and Sinus, Claritin-D 12 Hour, Clear-Atadine-D, Allergy Relief D12, Leader Allergy Relief D-24, Allergy & Congestion Relief, Allergy Relief D 24 Hour)
  • lorlatinib (Lorbrena)
  • losartan (Cozaar)
  • lovastatin (Mevacor, Altoprev, Altocor)
  • lovastatin / niacin (Advicor)
  • lurasidone (Latuda)
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  • olaparib (Lynparza)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • omeprazole / sodium bicarbonate (Zegerid, Zegerid OTC)
  • ondansetron (Zofran, Zofran ODT, Zuplenz)
  • osimertinib (Tagrisso)
  • oxybutynin (Ditropan, Ditropan XL, Oxytrol, Anturol, Gelnique, Urotrol, Oxytrol for Women)
  • oxycodone (OxyContin, Roxicodone, Xtampza ER, OxyIR, Oxaydo, Percolone, Oxyfast, Oxydose, RoxyBond, Dazidox, Oxecta, M-Oxy, ETH-Oxydose, Endocodone, Roxicodone Intensol)
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  • tacrolimus (Prograf, Envarsus XR, Astagraf XL, Hecoria)
  • tadalafil (Cialis, Adcirca)
  • tamoxifen (Nolvadex, Tamoxen, Tamosin, Tamofen, Tamoxifen Hexal, Soltamox, Tamone, Emblon, Nolvadex D, Genox)
  • tamsulosin (Flomax)
  • tasimelteon (Hetlioz)
  • temsirolimus (Torisel)
  • teniposide (Vumon)
  • terfenadine (Seldane)
  • testosterone (AndroGel, Depo-Testosterone, Androderm, Testim, Axiron, Testopel, Fortesta, Aveed, Delatestryl, Xyosted, Natesto, Vogelxo, Testoderm, Testopel Pellets, Striant, Testamone-100, Everone, FIRST-Testosterone MC, FIRST-Testosterone, Testro AQ, Testolin, Depotest, Virilon IM, Delatest, Andro LA 200, Andro-Cyp 100, Andro-Cyp 200, Depandro 100, Duratest, Durathate 200, Histerone, Meditest, Testro, Testro-LA, Testo-100)
  • testosterone topical
  • tiagabine (Gabitril)
  • ticagrelor (Brilinta)
  • tinidazole (Tindamax, Fasigyn)
  • tofacitinib (Xeljanz, Xeljanz XR)
  • tolazamide (Tolinase)
  • tolbutamide (Orinase, Tol-Tab)
  • tolterodine (Detrol, Detrol LA)
  • tolvaptan (Samsca, Jynarque)
  • toremifene (Fareston)
  • torsemide (Demadex, Demadex IV)
  • trabectedin (Yondelis)
  • trandolapril / verapamil (Tarka)
  • trazodone (Desyrel, Oleptro, Desyrel Dividose)
  • treprostinil (Remodulin, Orenitram, Tyvaso)
  • tretinoin (Vesanoid)
  • triamcinolone (Kenalog-40, Aristocort, Zilretta, Azmacort, Tramacort-D, Kenalog-10, Aristospan, Aristocort For Injection, Tristoject, Triamcot, Trilog, Aristospan Intra-Articular, Aristospan Intralesional, Aristopak, TAC 3, Triam-Forte, Triamonide 40, Triam-A, Kenaject-40, Cort-K, Trilone, U-Tri-Lone, Acetocot, Clinacort, Clinalog, Ken-Jec 40)
  • triazolam (Halcion)
  • troglitazone (Rezulin)
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Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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