Drug Interactions between L-Arginine and trametinib
This report displays the potential drug interactions for the following 2 drugs:
- L-Arginine (arginine)
- trametinib
Interactions between your drugs
No interactions were found between L-Arginine and trametinib. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
L-Arginine
A total of 44 drugs are known to interact with L-Arginine.
- L-arginine is in the following drug classes: in vivo diagnostic biologicals, oral nutritional supplements.
- L-arginine is used to treat the following conditions:
trametinib
A total of 33 drugs are known to interact with trametinib.
- Trametinib is in the drug class multikinase inhibitors.
- Trametinib is used to treat the following conditions:
Drug and food interactions
trametinib food
Applies to: trametinib
ADJUST DOSING INTERVAL: Food may reduce as well as delay the absorption of trametinib. In study subjects, administration of a single dose of trametinib with a high-fat, high-calorie meal decreased peak plasma concentration (Cmax) and systemic exposure (AUC) by 70% and 24%, respectively, and delayed Tmax by approximately 4 hours compared to administration in the fasted state.
MANAGEMENT: Trametinib should be taken at least 1 hour before or 2 hours after a meal.
References (1)
- (2013) "Product Information. Mekinist (trametinib)." GlaxoSmithKline
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Report options
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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