Drug Interactions between Hivid and Zepatier
This report displays the potential drug interactions for the following 2 drugs:
- Hivid (zalcitabine)
- Zepatier (elbasvir/grazoprevir)
Interactions between your drugs
No interactions were found between Hivid and Zepatier. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Hivid
A total of 144 drugs are known to interact with Hivid.
- Hivid is in the drug class nucleoside reverse transcriptase inhibitors (NRTIs).
- Hivid is used to treat HIV Infection.
Zepatier
A total of 226 drugs are known to interact with Zepatier.
- Zepatier is in the drug class antiviral combinations.
- Zepatier is used to treat Hepatitis C.
Drug and food interactions
zalcitabine food
Applies to: Hivid (zalcitabine)
Zalcitabine bioavailability may be decreased by 14% if taken with meals. The mechanism and clinical significance are unknown.
References
- "Product Information. HIVID (zalcitabine)." Roche Laboratories PROD (2001):
grazoprevir food
Applies to: Zepatier (elbasvir / grazoprevir)
Food does not appear to have clinically significant effects on the pharmacokinetics of elbasvir and grazoprevir. When a single 50 mg-100 mg dose of elbasvir-grazoprevir was administered to healthy study subjects with a high-fat meal (900 kcal; 500 kcal from fat), elbasvir peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 15% and 11%, respectively, while grazoprevir Cmax and AUC increased by 2.8- and 1.5-fold, respectively, compared to administration under fasting conditions. According to the product labeling, elbasvir-grazoprevir may be administered with or without food.
References
- "Product Information. Zepatier (elbasvir-grazoprevir)." Merck & Co., Inc (2016):
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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