Can you take Ferrous fumarate with Vitamin e?
1 drug interaction and 9 additional warnings found for the following 2 drugs:
- ferrous fumarate
- vitamin e
Drug interactions
Moderate drug interactions
Moderate:
vitamin E ferrous fumarate
Applies to: vitamin e and ferrous fumarate
Vitamin E may interfere with the effects of ferrous fumarate in the treatment of anemia.
Contact your doctor if your symptoms worsen or your condition changes.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
ferrous fumarate Food/Lifestyle
Applies to: ferrous fumarate
Food may reduce the absorption and blood levels of ferrous fumarate. In addition, some oral medications can also interfere with ferrous fumarate absorption into the bloodstream, which may make the medication less effective in treating your condition. Likewise, ferrous fumarate may interfere with the absorption of other orally administered medications.
You should take ferrous fumarate on an empty stomach at least one hour before or two hours after a meal.
Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications.
Talk to your doctor or pharmacist if you have questions about how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
8 potential interactions Applies to: 8 conditions, including Peptic Ulcer, Liver Disease, Noninfectious Colitis, Malabsorption Syndrome, and Blood Transfusion.
Achlorhydria
Moderate:
ferrous fumarate
Ferrous fumarate has a moderate potential interaction with Achlorhydria.
Gastric acidity increases iron bioavailability by maintaining the ingested iron in a reduced form as ferrous ions, which are more readily absorbed than ferric ions. Therefore, when iron therapy is administered orally, higher dosages may be necessary for patients with decreased gastric acid production. Also, a liquid formulation is recommended in these patients because dissolution of the tablet coating depends on normal gastric acidity.
Biliary Obstruction
Major:
vitamin e
vitamin E has a major potential interaction with Biliary Obstruction.
Vitamin E is fat soluble and many oral formulations require bile for adequate intestinal absorption. Hepatic and/or biliary dysfunction decrease the absorption of vitamin E. Water- miscible vitamin E formulations may be better absorbed from the GI tract under these conditions. Vitamin E is metabolized by the liver and primarily excreted in bile and feces. Hepatic and/or biliary impairment can alter the metabolic and therapeutic activity of vitamin E.
Blood Transfusion
Major:
ferrous fumarate
Ferrous fumarate has a major potential interaction with Blood Transfusion.
There is no excretory mechanism for iron. Iron will correct only hemoglobin abnormalities due to iron deficiency and should not be used to treat conditions such as thalassemia, hemosiderosis, hemochromatosis, normocytic anemia (unless iron deficiency exists), or in patients receiving blood transfusions. Clinical monitoring of erythropoietic function and ferritin levels is recommended.
Hemoglobinopathy
Major:
ferrous fumarate
Ferrous fumarate has a major potential interaction with Hemoglobinopathy.
There is no excretory mechanism for iron. Iron will correct only hemoglobin abnormalities due to iron deficiency and should not be used to treat conditions such as thalassemia, hemosiderosis, hemochromatosis, normocytic anemia (unless iron deficiency exists), or in patients receiving blood transfusions. Clinical monitoring of erythropoietic function and ferritin levels is recommended.
Liver Disease
Major:
vitamin e
vitamin E has a major potential interaction with Liver Disease.
Vitamin E is fat soluble and many oral formulations require bile for adequate intestinal absorption. Hepatic and/or biliary dysfunction decrease the absorption of vitamin E. Water- miscible vitamin E formulations may be better absorbed from the GI tract under these conditions. Vitamin E is metabolized by the liver and primarily excreted in bile and feces. Hepatic and/or biliary impairment can alter the metabolic and therapeutic activity of vitamin E.
Malabsorption Syndrome
Minor:
vitamin e
vitamin E has a minor potential interaction with Malabsorption Syndrome.
Vitamin E is readily absorbed from the intestinal tract in the presence of bile. Prolonged fat malabsorption (cystic fibrosis, hepatic cirrhosis, sprue) or malabsorption syndromes (celiac disease, GI resection) can decrease the absorption of many oral formulations of vitamin E. A water- miscible formulation of vitamin E may be better absorbed in these conditions.
Noninfectious Colitis
Moderate:
ferrous fumarate
Ferrous fumarate has a moderate potential interaction with Noninfectious Colitis.
Iron can be irritating and damaging to gastrointestinal mucosa. Iron therapy should be administered cautiously in patients with peptic ulcer disease, enteritis, or ulcerative colitis.
Peptic Ulcer
Moderate:
ferrous fumarate
Ferrous fumarate has a moderate potential interaction with Peptic Ulcer.
Iron can be irritating and damaging to gastrointestinal mucosa. Iron therapy should be administered cautiously in patients with peptic ulcer disease, enteritis, or ulcerative colitis.
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More resources
ferrous fumarate
A total of 89 drugs are known to interact with ferrous fumarate.
- Ferrous fumarate is in the drug class iron products.
- Ferrous fumarate is used to treat the following conditions:
vitamin e
A total of 273 drugs are known to interact with vitamin e.
- Vitamin e is in the drug class vitamins.
- Vitamin e is used to treat the following conditions:
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.