Drug Interactions between everolimus and trametinib
This report displays the potential drug interactions for the following 2 drugs:
- everolimus
- trametinib
Interactions between your drugs
No interactions were found between everolimus and trametinib. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
everolimus
A total of 513 drugs are known to interact with everolimus.
- Everolimus is in the following drug classes: mTOR inhibitors, selective immunosuppressants.
- Everolimus is used to treat the following conditions:
trametinib
A total of 20 drugs are known to interact with trametinib.
- Trametinib is in the drug class multikinase inhibitors.
- Trametinib is used to treat the following conditions:
Drug and food interactions
everolimus food
Applies to: everolimus
GENERALLY AVOID: Grapefruit juice may significantly increase the plasma concentrations of orally administered everolimus. The mechanism is inhibition of CYP450 3A4 and P-glycoprotein activity in the gut wall by certain compounds present in grapefruit.
MANAGEMENT: Patients treated with everolimus should avoid consumption of grapefruit and grapefruit juice.
References
- (2009) "Product Information. Afinitor (everolimus)." Novartis Pharmaceuticals
trametinib food
Applies to: trametinib
ADJUST DOSING INTERVAL: Food may reduce as well as delay the absorption of trametinib. In study subjects, administration of a single dose of trametinib with a high-fat, high-calorie meal decreased peak plasma concentration (Cmax) and systemic exposure (AUC) by 70% and 24%, respectively, and delayed Tmax by approximately 4 hours compared to administration in the fasted state.
MANAGEMENT: Trametinib should be taken at least 1 hour before or 2 hours after a meal.
References
- (2013) "Product Information. Mekinist (trametinib)." GlaxoSmithKline
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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