Drug Interactions between emtricitabine / tenofovir and Phenergan
This report displays the potential drug interactions for the following 2 drugs:
- emtricitabine/tenofovir
- Phenergan (promethazine)
Interactions between your drugs
No interactions were found between emtricitabine / tenofovir and Phenergan. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
emtricitabine / tenofovir
A total of 234 drugs are known to interact with emtricitabine / tenofovir.
- Emtricitabine / tenofovir is in the drug class antiviral combinations.
- Emtricitabine / tenofovir is used to treat the following conditions:
Phenergan
A total of 685 drugs are known to interact with Phenergan.
- Phenergan is in the following drug classes: antihistamines, phenothiazine antiemetics.
- Phenergan is used to treat the following conditions:
Drug and food interactions
promethazine food
Applies to: Phenergan (promethazine)
GENERALLY AVOID: Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment. Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines. The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.
MANAGEMENT: Patients should be advised to avoid alcohol during phenothiazine therapy.
References
- Lutz EG "Neuroleptic-induced akathisia and dystonia triggered by alcohol." JAMA 236 (1976): 2422-3
- Freed E "Alcohol-triggered-neuroleptic-induced tremor, rigidity and dystonia." Med J Aust 2 (1981): 44-5
tenofovir food
Applies to: emtricitabine / tenofovir
Food enhances the oral absorption and bioavailability of tenofovir, the active entity of tenofovir disoproxil fumarate. According to the product labeling, administration of the drug following a high-fat meal increased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of tenofovir by approximately 14% and 40%, respectively, compared to administration in the fasting state. However, administration with a light meal did not significantly affect the pharmacokinetics of tenofovir compared to administration in the fasting state. Food delays the time to reach tenofovir Cmax by approximately 1 hour. Tenofovir disoproxil fumarate may be administered without regard to meals.
References
- "Product Information. Viread (tenofovir)." Gilead Sciences (2001):
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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