Drug Interactions between docetaxel and trametinib
This report displays the potential drug interactions for the following 2 drugs:
Interactions between your drugs
No interactions were found between docetaxel and trametinib. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
- Docetaxel is in the drug class mitotic inhibitors.
- Docetaxel is used to treat the following conditions:
- Trametinib is in the drug class multikinase inhibitors.
- Trametinib is used to treat the following conditions:
Drug and food interactions
Applies to: docetaxel
You should preferably avoid the regular consumption of grapefruits and grapefruit juice while taking DOCEtaxel. Grapefruit and grapefruit juice can significantly increase the blood levels of DOCEtaxel. This may increase the risk of side effects such as nausea, vomiting, diarrhea, mouth sores, fluid retention, nerve pain, numbness, tingling, muscle pain or weakness, and impaired bone marrow function resulting in low numbers of different types of blood cells. You may also be more likely to develop anemia, bleeding problems, or infections due to low blood cell counts. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should contact your doctor if you develop paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Applies to: trametinib
Food may delay and reduce the absorption of trametinib, which may lead to lower blood levels of the medication and possibly reduced effectiveness. You should take trametinib at least 1 hour before or 2 hours after a meal.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.