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Drug Interactions between dimethyl fumarate and Myrbetriq

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

No interactions were found between dimethyl fumarate and Myrbetriq. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

dimethyl fumarate

A total of 617 drugs are known to interact with dimethyl fumarate.

Myrbetriq

A total of 231 drugs are known to interact with Myrbetriq.

Drug and food interactions

Minor

mirabegron food

Applies to: Myrbetriq (mirabegron)

Food reduces the oral absorption and bioavailability of mirabegron. According to the product labeling, administration of a 50 mg tablet with a high-fat meal decreased mirabegron peak plasma concentration (Cmax) and systemic exposure (AUC) by 45% and 17%, respectively, whereas administration with a low-fat meal decreased mirabegron Cmax and AUC by 75% and 51%, respectively. In phase 3 clinical studies demonstrating both safety and efficacy, mirabegron was administered without regards to food content and intake. Therefore, mirabegron can be taken with or without food at the recommended dosage.

References

  1. (2012) "Product Information. Myrbetriq (mirabegron)." Astellas Pharma US, Inc

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Minor

dimethyl fumarate food

Applies to: dimethyl fumarate

Food does not significantly affect the oral bioavailability of dimethyl fumarate. Administration of dimethyl fumarate with a high-fat, high-calorie meal did not affect the systemic exposure (AUC) to its active metabolite, monomethyl fumarate (MMF), but decreased its peak plasma concentration (Cmax) by 40% and prolonged the time to reach peak concentration (Tmax) from 2.0 hours to 5.5 hours. In the study, the incidence of flushing was reduced by approximately 25% in the fed state. Dimethyl fumarate may be taken with or without food; however, taking it with food may help reduce flushing.

References

  1. (2013) "Product Information. Tecfidera (dimethyl fumarate)." Biogen

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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