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Drug Interactions between Cycrin and lemborexant

This report displays the potential drug interactions for the following 2 drugs:

  • Cycrin (medroxyprogesterone)
  • lemborexant

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Interactions between your drugs

Moderate

medroxyPROGESTERone lemborexant

Applies to: Cycrin (medroxyprogesterone) and lemborexant

Lemborexant may decrease the blood levels and effects of medroxyPROGESTERone. You may need a dose adjustment if you have been taking medroxyPROGESTERone and are starting treatment with lemborexant. Contact your doctor if your condition changes during treatment with these medications. The interaction is not expected to occur if you are getting medroxyPROGESTERone by shot for birth control. However, let your doctor know if you experience bleeding outside of your menstrual cycle, since it may indicate reduced effectiveness of medroxyPROGESTERone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Major

lemborexant food

Applies to: lemborexant

Do not consume grapefruit, grapefruit juice, or any supplements that contain grapefruit extract during treatment with lemborexant unless directed otherwise by your doctor. Grapefruit juice can increase the blood levels of lemborexant. This may increase the risk of side effects such as central nervous system depression, abnormal sleep behaviors, worsening of depression or suicidal thoughts, changes in heartbeat, or headache. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.