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Drug Interactions between Choledyl and Vioxx

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

oxtriphylline rofecoxib

Applies to: Choledyl (oxtriphylline) and Vioxx (rofecoxib)

MONITOR: The coadministration with rofecoxib may increase the plasma concentrations of theophylline. The proposed mechanism is rofecoxib inhibition of CYP450 1A2, the isoenzyme primarily responsible for the metabolic clearance of theophylline. According to the manufacturer, rofecoxib (12.5 mg, 25 mg or 50 mg orally once daily for 7 days) increased the area under the plasma concentration-time curve (AUC) of theophylline (300 mg single dose) by 38% to 60% in a group of healthy subjects.

MANAGEMENT: Caution is advised during coadministration of theophylline with rofecoxib. Theophylline plasma levels should be closely monitored and the dosage adjusted accordingly, particularly following initiation, discontinuation or change of dosage of rofecoxib therapy in patients who are stabilized on their theophylline regimen. Patients should be advised to notify their physician if they experience signs of theophylline toxicity such as nausea, vomiting, diarrhea, headache, restlessness, insomnia, seizures, palpitations, and cardiac arrhythmia.

References

  1. (2001) "Product Information. Vioxx (rofecoxib)." Merck & Co., Inc

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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