Drug Interactions between ceftibuten and Valproate Sodium

Alcohol can increase the nervous system side effects of valproic acid such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with valproic acid. Do not use more than the recommended dose of valproic acid, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

The following interaction applies only if you are taking ceftibuten (brand name Cedax) in the liquid formulation:

Food may reduce the absorption of ceftibuten from the liquid (suspension) formulation, which may lead to lower blood levels of the medication and possibly reduced effectiveness. Therefore, it should be taken on an empty stomach at least two hours before or one hour after a meal. If you are taking the capsule formulation, you may take it with or without food. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.