Drug Interactions between candesartan and Hetlioz
This report displays the potential drug interactions for the following 2 drugs:
- candesartan
- Hetlioz (tasimelteon)
Interactions between your drugs
No interactions were found between candesartan and Hetlioz. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
candesartan
A total of 274 drugs are known to interact with candesartan.
- Candesartan is in the drug class angiotensin receptor blockers.
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Candesartan is used to treat the following conditions:
- Alport Syndrome (off-label)
- Heart Failure
- High Blood Pressure
- Migraine Prevention (off-label)
Hetlioz
A total of 412 drugs are known to interact with Hetlioz.
- Hetlioz is in the drug class miscellaneous anxiolytics, sedatives and hypnotics.
- Hetlioz is used to treat the following conditions:
Drug and food interactions
candesartan food
Applies to: candesartan
GENERALLY AVOID: Moderate-to-high dietary intake of potassium, especially salt substitutes, may increase the risk of hyperkalemia in some patients who are using angiotensin II receptor blockers (ARBs). ARBs can promote hyperkalemia through inhibition of angiotensin II-induced aldosterone secretion. Patients with diabetes, heart failure, dehydration, or renal insufficiency have a greater risk of developing hyperkalemia.
MANAGEMENT: Patients should receive dietary counseling and be advised to not use potassium-containing salt substitutes or over-the-counter potassium supplements without consulting their physician. If salt substitutes are used concurrently, regular monitoring of serum potassium levels is recommended. Patients should also be advised to seek medical attention if they experience symptoms of hyperkalemia such as weakness, irregular heartbeat, confusion, tingling of the extremities, or feelings of heaviness in the legs.
References
- "Product Information. Cozaar (losartan)." Merck & Co., Inc PROD (2001):
- "Product Information. Diovan (valsartan)." Novartis Pharmaceuticals PROD (2001):
tasimelteon food
Applies to: Hetlioz (tasimelteon)
GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of tasimelteon. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
ADJUST DOSING INTERVAL: Food may delay the absorption and onset of action of tasimelteon. According to the product labeling, administration of tasimelteon with a high-fat meal decreased peak plasma concentration (Cmax) by 44% and delayed the median time to reach Cmax by approximately 1.75 hours compared to administration in the fasted state.
MONITOR: Smoking induces CYP450 1A2 and may reduce the plasma concentrations of tasimelteon, which is metabolized by the isoenzyme. According to the product labeling, tasimelteon systemic exposure was approximately 40% lower in smokers than in nonsmokers.
MANAGEMENT: Patients receiving tasimelteon should be advised to avoid or limit consumption of alcohol. Tasimelteon should be taken without food. Patients who smoke may have a reduced therapeutic response to tasimelteon.
References
- "Product Information. Hetlioz (tasimelteon)." Vanda Pharmaceuticals Inc (2014):
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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