Drug Interactions between cabazitaxel and eliglustat
This report displays the potential drug interactions for the following 2 drugs:
- cabazitaxel
- eliglustat
Interactions between your drugs
No interactions were found between cabazitaxel and eliglustat. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
cabazitaxel
A total of 432 drugs are known to interact with cabazitaxel.
- Cabazitaxel is in the drug class mitotic inhibitors.
- Cabazitaxel is used to treat Prostate Cancer.
eliglustat
A total of 322 drugs are known to interact with eliglustat.
- Eliglustat is in the drug class miscellaneous metabolic agents.
- Eliglustat is used to treat Gaucher Disease.
Drug and food interactions
eliglustat food
Applies to: eliglustat
GENERALLY AVOID: Grapefruit juice may significantly increase the systemic exposure to eliglustat. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit. Because eliglustat is predicted to cause prolongation of the PR, QTc, and QRS cardiac intervals at substantially elevated plasma concentrations, consumption of grapefruit juice during treatment may increase the risk of bradycardia, atrioventricular block, cardiac arrest, and serious ventricular arrhythmias such as torsade de pointes.
MANAGEMENT: Patients treated with eliglustat should avoid consumption of grapefruit and grapefruit juice.
References
- "Product Information. Cerdelga (eliglustat)." Genzyme Corporation (2014):
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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