Drug Interactions between Bosulif and i3odine Max
This report displays the potential drug interactions for the following 2 drugs:
- Bosulif (bosutinib)
- i3odine Max (sodium iodide-i-131)
Interactions between your drugs
No interactions were found between Bosulif and i3odine Max. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Bosulif
A total of 533 drugs are known to interact with Bosulif.
- Bosulif is in the drug class BCR-ABL tyrosine kinase inhibitors.
- Bosulif is used to treat Chronic Myelogenous Leukemia.
i3odine Max
A total of 165 drugs are known to interact with i3odine Max.
- I3odine max is in the following drug classes: antithyroid agents, therapeutic radiopharmaceuticals.
- I3odine max is used to treat the following conditions:
Drug and food interactions
sodium iodide I-131 food
Applies to: i3odine Max (sodium iodide-i-131)
MONITOR: Excessive intake of dietary iodine (e.g., iodised salt) may interfere with adequate uptake of radioiodide by the thyroid .
MANAGEMENT: A diet low in iodine is recommended before initiating therapy with sodium iodide I-131 or I-123.
References
- Cerner Multum, Inc. "Australian Product Information."
bosutinib food
Applies to: Bosulif (bosutinib)
ADJUST DOSING INTERVAL: Food enhances the oral bioavailability of bosutinib. When given with a high-fat meal, bosutinib peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 1.8- and 1.7-fold, respectively.
GENERALLY AVOID: Coadministration with grapefruit juice is likely to increase the plasma concentrations of bosutinib, which is primarily metabolized by CYP450 3A4. However, the interaction has not been studied. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit.
MANAGEMENT: Bosutinib should be administered with a meal. The consumption of grapefruit, grapefruit juice, and supplements that contain grapefruit extract should be avoided.
References
- (2012) "Product Information. Bosulif (bosutinib)." Pfizer U.S. Pharmaceuticals Group
sodium iodide I-131 food
Applies to: i3odine Max (sodium iodide-i-131)
ADJUST DOSING INTERVAL: Certain drugs may affect the pharmacokinetics, pharmacodynamics, and/or diagnostic results of radioiodides.
MANAGEMENT: Antithyroid agents such as carbimazole or propylthiouracil should generally be withheld for 1 week before administration of sodium iodide I-131 or I-123, and for a few days afterward. Salicylates, steroids, anticoagulants, antihistamines, antiparasitics, penicillins, sulfonamides, tolbutamide, thiopental, and nitroprusside should generally be withheld for 1 week. Amiodarone, lithium, and benzodiazepines should be withheld for at least 4 weeks.
References
- (2022) "Product Information. Sodium Iodide I-123 (sodium iodide I-123)." GE Healthcare
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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