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Can you take Bentyl with CidalEaze?

No drug interactions found, but 28 warnings to review for the following 2 drugs:

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Drug interactions

There were no interactions found between Bentyl and CidalEaze. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Food/lifestyle interactions

Moderate food/lifestyle interactions

Moderate:

dicyclomine Alcohol (Ethanol)

Applies to: Bentyl (dicyclomine)

Ask your doctor before using dicyclomine together with ethanol (alcohol).

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking dicyclomine.

You should be warned not to exceed recommended dosages and to avoid activities requiring mental alertness.

If your doctor prescribes these medications together, you may need a dose adjustment to safely take this combination.

It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Minor food/lifestyle interactions

Minor:

lidocaine topical Food/Lifestyle

Applies to: CidalEaze (lidocaine topical)

Theoretically, grapefruit, grapefruit juice, grapefruit hybrids, starfruit, and Seville oranges may increase the plasma concentrations of topical lidocaine. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit. Inhibition of hepatic CYP450 3A4 may also contribute. In a drug study when a single dose of intravenous lidocaine was coadministered with potent CYP450 3A4 inhibitors, erythromycin and itraconazole, lidocaine plasma clearance was reduced by 9 to 18% in healthy subjects. The degree of systemic absorption of topical lidocaine is dependent on the duration of application, the applied surface area, and the integrity of the application site. The risk of systemic lidocaine absorption may be greater when topical lidocaine is applied to areas of high systemic absorption (e.g., mucous membranes) with repeated doses over a long period of time. However, the clinical significance of this potential interaction is unknown.

The information above is from our professional interaction data. Consumer information is not available for this interaction.

Disease interactions

26 potential interactions Applies to: 23 conditions, including High Blood Pressure, GERD, Seizures, Arrhythmia, and Hyperthyroidism.

Arrhythmia

Moderate:

Bentyl

The dicyclomine in Bentyl has a moderate potential interaction with Arrhythmia.

Antimuscarinic agents block vagal inhibition of the SA nodal pacemaker. These agents should be administered cautiously in patients with tachycardia, congestive heart failure, or coronary artery disease. Premature ventricular depolarization or ventricular tachycardia or fibrillation associated with antimuscarinic drugs is rare.

Autonomic Neuropathy

Major:

Bentyl

The dicyclomine in Bentyl has a major potential interaction with Autonomic Neuropathy.

Agents with anticholinergic activity can exacerbate many of the manifestations of autonomic neuropathy, including tachycardia, anhidrosis, bladder atony, obstipation, dry mouth and eyes, cycloplegia and blurring of vision, and sexual impotence in males. Therapy with antimuscarinic agents and higher dosages of antispasmodic agents (e.g., dicyclomine or oxybutynin) should be administered cautiously in patients with autonomic neuropathy.

Cardiovascular Conditions and Disorders

Major:

Bentyl

The dicyclomine in Bentyl has a major potential interaction with Cardiovascular Conditions and Disorders.

Therapy with dicyclomine is contraindicated in patients with unstable cardiovascular status in acute hemorrhage.

Esophageal Obstruction

Major:

Bentyl

The dicyclomine in Bentyl has a major potential interaction with Esophageal Obstruction.

Anticholinergics are contraindicated in patients with obstructive diseases such as achalasia, esophageal stricture or stenosis, pyloroduodenal stenosis, stenosing peptic ulcer, pyloric obstruction, and paralytic ileus. Anticholinergics may further suppress intestinal motility with resultant precipitation or aggravation of toxic megacolon.

Fever

Minor:

Bentyl

The dicyclomine in Bentyl has a minor potential interaction with Fever.

Atropine-like agents may increase the risk of hyperthermia in patients with fever by producing anhidrosis. Therapy with atropine-like agents should be administered cautiously in febrile patients.

Gastrointestinal Obstruction

Major:

Bentyl

The dicyclomine in Bentyl has a major potential interaction with Gastrointestinal Obstruction.

Anticholinergics are contraindicated in patients with obstructive diseases such as achalasia, esophageal stricture or stenosis, pyloroduodenal stenosis, stenosing peptic ulcer, pyloric obstruction, and paralytic ileus. Anticholinergics may further suppress intestinal motility with resultant precipitation or aggravation of toxic megacolon.

GERD

Major:

Bentyl

The dicyclomine in Bentyl has a major potential interaction with GERD.

Therapy with dicyclomine is contraindicated in patients with reflux esophagitis.

Moderate:

Bentyl

The dicyclomine in Bentyl has a moderate potential interaction with GERD.

Antimuscarinic agents decrease gastric motility and relax the lower esophageal sphincter which promotes gastric retention and can aggravate reflux. These drugs should be administered cautiously in patients with gastroesophageal reflux or hiatal hernia associated with reflux esophagitis.

Glaucoma/Intraocular Hypertension

Major:

Bentyl

The dicyclomine in Bentyl has a major potential interaction with Glaucoma/Intraocular Hypertension.

Anticholinergic agents are contraindicated in patients with primary glaucoma, a tendency toward glaucoma (narrow anterior chamber angle), or adhesions (synechiae) between the iris and lens, as well as for the elderly and others in whom undiagnosed glaucoma or excessive pressure in the eye may be present. Because anticholinergics cause mydriasis, they may exacerbate these conditions.

Heart Block

Major:

CidalEaze

The lidocaine topical in CidalEaze has a major potential interaction with Heart Block.

Lidocaine is absorbed through intact skin and mucosal membranes following topical administration. Prolonged exposure, large doses, frequent applications and/or use on compromised skin or mucosa can produce systemic effects. At high plasma levels, lidocaine can cause hypotension, bradycardia, and cardiovascular collapse. Therapy with lidocaine topical should be administered cautiously in patients with shock, sinus bradyarrhythmia, or severe heart block. The recommended dosage should not be exceeded. Children and debilitated, elderly, or acutely ill patients should be given reduced dosages commensurate with their age, weight, and physical condition.

High Blood Pressure

Minor:

Bentyl

The dicyclomine in Bentyl has a minor potential interaction with High Blood Pressure.

Cardiovascular effects of anticholinergics may exacerbate hypertension. Therapy with anticholinergic agents should be administered cautiously in patients with hypertension.

Hyperthyroidism

Moderate:

Bentyl

The dicyclomine in Bentyl has a moderate potential interaction with Hyperthyroidism.

Caution is recommended when using dicyclomine in patients with hyperthyroidism.

Infectious Gastroenteritis

Major:

Bentyl

The dicyclomine in Bentyl has a major potential interaction with Infectious Gastroenteritis.

The use of drugs with antiperistaltic activity (primarily antidiarrheal and antimuscarinic agents, but also antispasmodic agents such as dicyclomine or oxybutynin at high dosages) is contraindicated in patients with diarrhea due to pseudomembranous enterocolitis or enterotoxin-producing bacteria. These drugs may prolong and/or worsen diarrhea associated with organisms that invade the intestinal mucosa, such as toxigenic E. coli, Salmonella and Shigella, and pseudomembranous colitis due to broad-spectrum antibiotics. Other symptoms and complications such as fever, shedding of organisms and extraintestinal illness may also be increased or prolonged. In general, because antiperistaltic agents decrease gastrointestinal motility, they may delay the excretion of infective gastroenteric organisms or toxins and should be used cautiously in patients with any infectious diarrhea, particularly if accompanied by high fever or pus or blood in the stool. Some cough and cold and other combination products may occasionally include antimuscarinic agents for their drying effects and may, therefore, require careful selection when necessary.

Ischemic Heart Disease

Moderate:

Bentyl

The dicyclomine in Bentyl has a moderate potential interaction with Ischemic Heart Disease.

Antimuscarinic agents block vagal inhibition of the SA nodal pacemaker. These agents should be administered cautiously in patients with tachycardia, congestive heart failure, or coronary artery disease. Premature ventricular depolarization or ventricular tachycardia or fibrillation associated with antimuscarinic drugs is rare.

Liver Disease

Major:

CidalEaze

The lidocaine topical in CidalEaze has a major potential interaction with Liver Disease.

Lidocaine topical is absorbed through intact skin and mucosal membranes. Prolonged exposure, large doses, and/or application to compromised skin or mucosa can result in elevated plasma concentrations of lidocaine. Lidocaine is rapidly and extensively metabolized by the liver. Less than 10% is eliminated unchanged in the urine. Several inactive and two active forms (MEGX and GX) have been identified. MEGX and GX exhibit antiarrhythmic and convulsant properties. The pharmacokinetic disposition of lidocaine is altered by changes in hepatic function, including hepatic blood flow. Therapy with lidocaine topical should be administered cautiously and dosing modified for patients with compromised hepatic function.

Moderate:

Bentyl

The dicyclomine in Bentyl has a moderate potential interaction with Liver Disease.

Effects of hepatic impairment on pharmacokinetics, safety and efficacy of dicyclomine have not been studied. Dicyclomine should be administered with caution in patients with hepatic impairment.

Myasthenia Gravis

Major:

Bentyl

The dicyclomine in Bentyl has a major potential interaction with Myasthenia Gravis.

Because antimuscarinic agents have anticholinergic effects, they are contraindicated in patients with myasthenia gravis. Their use may be appropriate to reduce adverse muscarinic effects caused by an anticholinesterase agent.

Psychosis

Moderate:

Bentyl

The dicyclomine in Bentyl has a moderate potential interaction with Psychosis.

Toxic psychosis manifested as confusion, disorientation, agitation, excitation, memory impairment, delusions and hallucinations may develop at toxic and therapeutic dosages of antimuscarinic agents. Therapy with these agents should be administered cautiously in patients with mental disorders receiving antimuscarinic agents for control of drug-induced extrapyramidal effects, especially at the beginning of therapy or during dosage adjustment. Psychiatric deterioration and psychotic flare-ups have also been reported following withdrawal of therapy. Symptoms include delusions, hallucinations, aggression or violent behavior, and suicidal tendencies. In high dosages, antimuscarinic agents may sometimes produce euphorigenic effects. For this reason, it can be a drug of abuse.

Renal Dysfunction

Major:

CidalEaze

The lidocaine topical in CidalEaze has a major potential interaction with Renal Dysfunction.

Lidocaine topical is absorbed through intact skin and mucosal membranes. Prolonged exposure, large doses, and/or application to compromised skin or mucosa can result in elevated plasma concentrations of lidocaine. Lidocaine is primarily eliminated by the kidney. Less than 10% is eliminated unchanged in the urine. Two active metabolites (MEGX and GX) have been identified that exhibit antiarrhythmic and convulsant properties. Serum concentrations of lidocaine and the active metabolites are increased and the half-life prolonged in patients with renal impairment. Therapy with lidocaine topical should be administered cautiously and dosing modified for repeated doses in patients with compromised renal function.

Moderate:

Bentyl

The dicyclomine in Bentyl has a moderate potential interaction with Renal Dysfunction.

Effects of renal impairment on pharmacokinetics, safety and efficacy of dicyclomine have not been studied. Dicyclomine is substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Dicyclomine should be administered with caution in patients with renal impairment.

Seizures

Major:

CidalEaze

The lidocaine topical in CidalEaze has a major potential interaction with Seizures.

Lidocaine topical is absorbed through intact skin and mucosal membranes. Prolonged exposure, large doses, and/or application to compromised skin or mucosa can result in elevated plasma concentrations of lidocaine. Seizures can occur as a result of accumulation of active metabolites. Therapy with lidocaine topical should be administered cautiously to patients with or predisposed to seizure disorders.

Shock

Major:

CidalEaze

The lidocaine topical in CidalEaze has a major potential interaction with Shock.

Lidocaine is absorbed through intact skin and mucosal membranes following topical administration. Prolonged exposure, large doses, frequent applications and/or use on compromised skin or mucosa can produce systemic effects. At high plasma levels, lidocaine can cause hypotension, bradycardia, and cardiovascular collapse. Therapy with lidocaine topical should be administered cautiously in patients with shock, sinus bradyarrhythmia, or severe heart block. The recommended dosage should not be exceeded. Children and debilitated, elderly, or acutely ill patients should be given reduced dosages commensurate with their age, weight, and physical condition.

Tardive Dyskinesia

Major:

Bentyl

The dicyclomine in Bentyl has a major potential interaction with Tardive Dyskinesia.

Anticholinergic agents and agents with secondary anticholinergic activity may aggravate tardive dyskinesia or induce previously suppressed symptoms. Therapy with these agents should be avoided, if possible, or administered cautiously in patients with preexisting tardive dyskinesia, particularly in the elderly. If tardive dyskinesia symptoms develop or worsen during treatment with an anticholinergic agent, prompt withdrawal of therapy will provide better chances of improving the condition.

Teething Syndrome

Major:

CidalEaze

The lidocaine topical in CidalEaze has a major potential interaction with Teething Syndrome.

Topical lidocaine is not recommended to be used in teething infants and young children, as its ingestion is dangerous and potentially fatal. Ingestion of the drug has shown to result in seizures, severe brain injury, and heart problems in children.

Ulcerative Colitis

Major:

Bentyl

The dicyclomine in Bentyl has a major potential interaction with Ulcerative Colitis.

Therapy with dicyclomine is contraindicated in patients with severe ulcerative colitis. Antimuscarinic agents, such as dicyclomine may suppress intestinal motility and produce paralytic ileus with resultant precipitation of toxic megacolon. Antimuscarinic agents should be administered cautiously to patients with ulcerative colitis.

Urinary Retention

Major:

Bentyl

The dicyclomine in Bentyl has a major potential interaction with Urinary Retention.

In general, the use of anticholinergic agents is contraindicated in patients with urinary retention and bladder neck obstruction caused by prostatic hypertrophy. Dysuria may occur and may require catheterization. Also, anticholinergic drugs may aggravate partial obstructive uropathy. Caution is advised even when using agents with mild to moderate anticholinergic activity, particularly in elderly patients.

More resources

Bentyl

A total of 223 drugs are known to interact with Bentyl.

CidalEaze

A total of 121 drugs are known to interact with CidalEaze.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.