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Can you take Anti-thymocyte globulin (rabbit) with Vitamin e?

1 drug interaction and 7 additional warnings found for the following 2 drugs:

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Drug interactions

Minor drug interactions

Minor:

vitamin E anti-thymocyte globulin (rabbit)

Applies to: vitamin e and anti-thymocyte globulin (rabbit)

Information for this minor interaction is available on the professional version.

Food/lifestyle interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease interactions

7 potential interactions Applies to: 7 conditions, including Liver Disease, Infection, Immunodeficiency, Malabsorption Syndrome, and Biliary Obstruction.

Biliary Obstruction

Major:

vitamin e

vitamin E has a major potential interaction with Biliary Obstruction.

Vitamin E is fat soluble and many oral formulations require bile for adequate intestinal absorption. Hepatic and/or biliary dysfunction decrease the absorption of vitamin E. Water- miscible vitamin E formulations may be better absorbed from the GI tract under these conditions. Vitamin E is metabolized by the liver and primarily excreted in bile and feces. Hepatic and/or biliary impairment can alter the metabolic and therapeutic activity of vitamin E.

Bone Marrow Depression/Low Blood Counts

Major:

anti-thymocyte globulin (rabbit)

Anti-thymocyte globulin (rabbit) has a major potential interaction with Bone Marrow Depression/Low Blood Counts.

The use of anti-thymocyte globulin [rabbit] is contraindicated in patients who have active acute or chronic infections that contraindicate any additional immunosuppression. To prevent over-immunosuppression, physicians may wish to decrease the dose of the maintenance immunosuppression regimen during the period of therapy use. Low counts of platelets and white blood cells (including low counts of lymphocytes and neutrophils) have been identified and are reversible following dose adjustments. It is recommended to monitor patients carefully and administer appropriate anti-infective treatment when indicated. Also, total white blood cell and platelet counts should be monitored.

Immunodeficiency

Major:

anti-thymocyte globulin (rabbit)

Anti-thymocyte globulin (rabbit) has a major potential interaction with Immunodeficiency.

The use of anti-thymocyte globulin [rabbit] is contraindicated in patients who have active acute or chronic infections that contraindicate any additional immunosuppression. To prevent over-immunosuppression, physicians may wish to decrease the dose of the maintenance immunosuppression regimen during the period of therapy use. Low counts of platelets and white blood cells (including low counts of lymphocytes and neutrophils) have been identified and are reversible following dose adjustments. It is recommended to monitor patients carefully and administer appropriate anti-infective treatment when indicated. Also, total white blood cell and platelet counts should be monitored.

Infection

Major:

anti-thymocyte globulin (rabbit)

Anti-thymocyte globulin (rabbit) has a major potential interaction with Infection.

The use of anti-thymocyte globulin [rabbit] is contraindicated in patients who have active acute or chronic infections that contraindicate any additional immunosuppression. To prevent over-immunosuppression, physicians may wish to decrease the dose of the maintenance immunosuppression regimen during the period of therapy use. Low counts of platelets and white blood cells (including low counts of lymphocytes and neutrophils) have been identified and are reversible following dose adjustments. It is recommended to monitor patients carefully and administer appropriate anti-infective treatment when indicated. Also, total white blood cell and platelet counts should be monitored.

Liver Disease

Major:

vitamin e

vitamin E has a major potential interaction with Liver Disease.

Vitamin E is fat soluble and many oral formulations require bile for adequate intestinal absorption. Hepatic and/or biliary dysfunction decrease the absorption of vitamin E. Water- miscible vitamin E formulations may be better absorbed from the GI tract under these conditions. Vitamin E is metabolized by the liver and primarily excreted in bile and feces. Hepatic and/or biliary impairment can alter the metabolic and therapeutic activity of vitamin E.

Malabsorption Syndrome

Minor:

vitamin e

vitamin E has a minor potential interaction with Malabsorption Syndrome.

Vitamin E is readily absorbed from the intestinal tract in the presence of bile. Prolonged fat malabsorption (cystic fibrosis, hepatic cirrhosis, sprue) or malabsorption syndromes (celiac disease, GI resection) can decrease the absorption of many oral formulations of vitamin E. A water- miscible formulation of vitamin E may be better absorbed in these conditions.

Vaccination

Major:

anti-thymocyte globulin (rabbit)

Anti-thymocyte globulin (rabbit) has a major potential interaction with Vaccination.

Patients recently treated with anti-thymocyte globulin [rabbit] should not receive immunizations with live viral vaccines.

More resources

anti-thymocyte globulin (rabbit)

A total of 180 drugs are known to interact with anti-thymocyte globulin (rabbit).

vitamin e

A total of 273 drugs are known to interact with vitamin e.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.