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Drug Interactions between Allegra-D 12 Hour and Flexeril

This report displays the potential drug interactions for the following 2 drugs:

  • Allegra-D 12 Hour (fexofenadine/pseudoephedrine)
  • Flexeril (cyclobenzaprine)

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Interactions between your drugs

No interactions were found between Allegra-D 12 Hour and Flexeril. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Allegra-D 12 Hour

A total of 217 drugs are known to interact with Allegra-D 12 Hour.


A total of 372 drugs are known to interact with Flexeril.

Drug and food interactions


cyclobenzaprine food

Applies to: Flexeril (cyclobenzaprine)

Alcohol can increase the nervous system side effects of cyclobenzaprine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with cyclobenzaprine. Do not use more than the recommended dose of cyclobenzaprine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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fexofenadine food

Applies to: Allegra-D 12 Hour (fexofenadine / pseudoephedrine)

Consuming large amounts of certain fruit juices, including grapefruit, orange and apple, may decrease the levels of fexofenadine in your body. Fexofenadine should be taken with water and refrain from drinking large amounts of grapefruit, orange, or apple juice. This will make it easier for your body to absorb the medication.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.