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Voluven Dosage

Generic name: HYDROXYETHYL STARCH 130/0.4 6g in 100mL
Dosage form: injection, solution
Drug class: Plasma expanders

Medically reviewed by Last updated on Dec 5, 2022.

Voluven ® is administered by intravenous infusion only. The daily dose and rate of infusion depend on the patient’s blood loss, on the maintenance or restoration of hemodynamics and on the hemodilution (dilution effect). Voluven ® can be administered repetitively over several days. [see Warnings and Precautions (5)]

The initial 10 to 20 mL should be infused slowly, keeping the patient under close observation due to possible anaphylactoid reactions. [see General Warnings and Precautions (5.1)]

Adult Dose

Up to 50 mL of Voluven ® per kg of body weight per day (equivalent to 3 g hydroxyethyl starch and 7.7 mEq sodium per kg of body weight). This dose is equivalent to 3500 mL of Voluven ® for a 70 kg patient.

Pediatric Dose

The dosage in children should be adapted to the individual patient colloid needs, taking into account the disease state, as well as the hemodynamic and hydration status.

In 41 newborns to infants (< 2 years), a mean dose of 16 ± 9 mL/kg was administered. In 31 children from 2 to 12 years of age a mean dose of 36 ± 11 mL/kg was administered. The dose in adolescents > 12 is the same as the adult dose. [see Pediatric Use (8.4)]

Directions for Use of Voluven





  1. Do not remove the freeflex ® IV container from its overwrap until immediately before use.
  2. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
  3. Do not administer unless the solution is clear, free from particles and the freeflex® IV container is undamaged.
  4. Voluven ® should be used immediately after insertion of the administration set.
  5. Do not vent.
  6. If administered by pressure infusion, air should be withdrawn or expelled from the bag through the medication/administration port prior to infusion.
  7. Discontinue the infusion if an adverse reaction occurs.
  8. It is recommended that administration sets be changed at least once every 24 hours.
  9. For single use only. Discard unused portion.

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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.