Tromethamine Dosage
Applies to the following strengths: 3.6 g/100 mL
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Metabolic Acidosis
Associated with Cardiac Bypass Surgery:
Initial dose: 500 mL (150 mEq) by slow intravenous infusion is considered adequate for most adults; up to 1000 mL may be required in severe cases
Maximum dose: 500 mg/kg (227 mg/lb) over a period of not less than one hour
Associated with Cardiac Arrest:
If the chest is open: 2 to 6 g (62 to 185 mL of a 0.3 M solution) injected into the ventricular cavity
If the chest is not open: 3.6 to 10.8 g (111 to 333 mL of a 0.3 M solution) injected into a larger peripheral vein if the chest is not open
Comment: Do not inject into the cardiac muscle
Usual Pediatric Dose for Metabolic Acidosis
Associated with RDS in Neonates and Infants:
1 mL/kg for each pH unit below 7.4
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Dose Adjustments
Dosage should be limited to an amount sufficient to increase blood pH to normal limits (7.35 to 7.45) and to correct acid-base derangements
Estimate the IV dosage of tromethamine injection from the buffer base deficit of the extracellular fluid in mEq/liter determined by means of the Siggaard-Andersen nomogram.
Use the following formula as a general guide:
Tromethamine solution (mL of 0.3 M) required =
Body Weight (kg) X
Base Deficit (mEq/liter) X 1.1
Note: Factor of 1.1 accounts for an approximate reduction of 10% in buffering capacity due to the presence of sufficient acetic acid to lower pH of the 0.3 M solution to approximately 8.6
Precautions
Consult WARNINGS section for dosing related precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- Administer by slow intravenous infusion by addition to pump-oxygenator ACD blood or other priming fluid or by injection into the ventricular cavity during cardiac arrest
- Use a large needle in the largest antecubital vein or an indwelling catheter placed in a large vein of a limb for infusion in a peripheral vein
- Catheters are recommended
Reconstitution/preparation techniques:
- Do not administer unless solution is clear and the seal is intact
- Discard unused portion
IV compatibility:
- Additives may be incompatible
- When introducing additives, use aseptic technique, mix thoroughly and do not store
Monitoring: Pretreatment and subsequent determinations of blood values (pH, PCO2, PO2, glucose and electrolytes) and urinary output should be made as necessary to monitor dosage and the progress of treatment.
More about tromethamine
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- Drug class: minerals and electrolytes
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.