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Saquinavir Dosage

Medically reviewed by Drugs.com. Last updated on May 23, 2023.

Applies to the following strengths: mesylate 500 mg; mesylate 200 mg; 200 mg

Usual Adult Dose for HIV Infection

Standard dose: Saquinavir 1000 mg plus ritonavir 100 mg orally twice a day

Therapy-naive patients (starting therapy with saquinavir/ritonavir):


Patients switching immediately (no washout period) from another ritonavir-containing regimen or from a NNRTI-based regimen (excluding delavirdine, rilpivirine): Saquinavir 1000 mg plus ritonavir 100 mg orally twice a day

Patients switching from a regimen containing delavirdine:

Use: In combination with ritonavir and other antiretrovirals, for the treatment of HIV-1 infection

Usual Adult Dose for Nonoccupational Exposure

US CDC Recommendations: Saquinavir 1000 mg plus ritonavir 100 mg orally twice a day
Duration of therapy: 28 days

Comments:

Usual Adult Dose for Occupational Exposure

US Public Health Service Working Group Recommendations: Saquinavir 1000 mg plus ritonavir 100 mg orally twice a day
Duration of therapy: 28 days, if tolerated

Comments:

Usual Pediatric Dose for HIV Infection

16 years or older:
Standard dose: Saquinavir 1000 mg plus ritonavir 100 mg orally twice a day

Therapy-naive patients (starting therapy with saquinavir/ritonavir):


Patients switching immediately (no washout period) from another ritonavir-containing regimen or from a NNRTI-based regimen (excluding delavirdine, rilpivirine): Saquinavir 1000 mg plus ritonavir 100 mg orally twice a day

Patients switching from a regimen containing delavirdine:

Comments:

Use: In combination with ritonavir and other antiretrovirals, for the treatment of HIV-1 infection

Renal Dose Adjustments

Mild or moderate renal dysfunction: No adjustment recommended.
Severe renal dysfunction or ESRD: No adjustment recommended; caution recommended.

Liver Dose Adjustments

Mild or moderate liver dysfunction: No adjustment recommended.
Severe liver dysfunction: Contraindicated

Comments:

Dose Adjustments

If serious or severe toxicity occurs during therapy, saquinavir/ritonavir should be discontinued.

Precautions

CONTRAINDICATIONS:
In Combination with Ritonavir:


Consult WARNINGS section for additional precautions.

Safety and efficacy have not been established in patients younger than 16 years.

Dialysis

Data not available

Comments:

Other Comments

Administration advice:


Storage requirements:

General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.