Generic name: HUMAN RHO(D) IMMUNE GLOBULIN 1500[iU] in 2mL
Dosage form: injection
Medically reviewed by Drugs.com. Last updated on May 6, 2020.
As with all blood products, patients should be observed for at least 20 minutes following administration of Rhophylac.
Preparation and Handling
Rhophylac is a clear or slightly opalescent, colorless to pale yellow solution. Inspect Rhophylac visually for particulate matter and discoloration prior to administration. Do not use if the solution is cloudy or contains particulates.
Prior to intravenous use, ensure that the needle-free intravenous administration system is compatible with the tip of the Rhophylac glass syringe.
Do not freeze.
Bring Rhophylac to room temperature before use.
Rhophylac is for single use only. Dispose of any unused product or waste material in accordance with local requirements.
Suppression of Rh Isoimmunization
Rhophylac should be administered by intravenous or intramuscular injection. If large doses (greater than 5 mL) are required and intramuscular injection is chosen, it is advisable to administer Rhophylac in divided doses at different sites.
Ensure the site of administration will allow the injection to reach the muscle if Rhophylac is administered intramuscularly. Consider intravenous administration if reaching the muscle is of concern [see Adverse Reactions (6.2)]. Do not administer Rhophylac subcutaneously into the fatty tissue.
Table 1 provides dosing guidelines based on the condition being treated.
|Indication||Timing of Administration||Dose*
(Administer by Intravenous or Intramuscular Injection)
|IU, international units; mcg, micrograms.|
||At Week 28-30 of gestation||1500 IU (300 mcg)|
||Within 72 hours of birth||1500 IU (300 mcg)†|
||Within 72 hours of complication||1500 IU (300 mcg)†|
||Within 72 hours of procedure||1500 IU (300 mcg)†|
||Within 72 hours of complication||1500 IU (300 mcg) plus:
|Incompatible transfusions||Within 72 hours of exposure||100 IU (20 mcg)
per 2 mL transfused blood or per 1 mL erythrocyte concentrate
For treatment of ITP, ADMINISTER RHOPHYLAC BY THE INTRAVENOUS ROUTE ONLY [see Dosage and Administration (2.1)]. Do not administer intramuscularly.
A 250 IU (50 mcg) per kg body weight dose of Rhophylac is recommended for patients with ITP. The following formula can be used to calculate the recommended amount of Rhophylac to administer:
Dose (IU) × body weight (kg) = Total IU / 1500 IU per syringe = Number of syringes
Rhophylac should be administered at a rate of 2 mL per 15 to 60 seconds.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about Rhophylac (rho (d) immune globulin)
- Side Effects
- During Pregnancy or Breastfeeding
- Drug Interactions
- Pricing & Coupons
- En Español
- Drug class: immune globulins
- FDA Approval History