Skip to main content

Novocain Dosage

Generic name: procaine hydrochloride
Dosage form: injection, USP
Drug class: Local injectable anesthetics

Medically reviewed by Last updated on Aug 18, 2023.

As with all local anesthetics, the dose of NOVOCAIN varies and depends upon the area to be anesthetized, the vascularity of the tissues, the number of neuronal segments to be blocked, individual tolerance, and the technique of anesthesia. The lowest dose needed to provide effective anesthesia should be administered. For specific techniques and procedures, refer to standard textbooks.

Extent of Anesthesia NOVOCAIN

10% Solution

Total Dose


Site of Injection

(lumbar interspace)

Volume of 10% Solution


Volume of Dilution


Perineum 0.5 0.5 50 4th
Perineum and lower


1 1 100 3rd or 4th
Up to costal margin 2 1 200 2nd, 3rd or 4th

The diluent may be sterile normal saline, sterile distilled water, spinal fluid; and for hyperbaric technique, sterile dextrose solution.

The usual rate of injection is 1 mL per 5 seconds. Full anesthesia and fixation usually occur in 5 minutes.


The drug in intact ampuls is sterile. The preferred method of destroying bacteria on the exterior of ampuls before opening is heat sterilization (autoclaving). Immersion in antiseptic solution is not recommended.

Autoclave at 15-pound pressure, at 121°C (250°F), for 15 minutes. The diluent dextrose may show some brown discoloration due to caramelization.

Protect solutions from light.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.