Generic name: procaine hydrochloride
Dosage form: injection, USP
Medically reviewed by Drugs.com. Last updated on Aug 19, 2019.
As with all local anesthetics, the dose of NOVOCAIN varies and depends upon the area to be anesthetized, the vascularity of the tissues, the number of neuronal segments to be blocked, individual tolerance, and the technique of anesthesia. The lowest dose needed to provide effective anesthesia should be administered. For specific techniques and procedures, refer to standard textbooks.
|Extent of Anesthesia||NOVOCAIN
|Site of Injection
|Volume of 10% Solution
|Volume of Dilution
|Perineum and lower
|1||1||100||3rd or 4th|
|Up to costal margin||2||1||200||2nd, 3rd or 4th|
The diluent may be sterile normal saline, sterile distilled water, spinal fluid; and for hyperbaric technique, sterile dextrose solution.
The usual rate of injection is 1 mL per 5 seconds. Full anesthesia and fixation usually occur in 5 minutes.
The drug in intact ampuls is sterile. The preferred method of destroying bacteria on the exterior of ampuls before opening is heat sterilization (autoclaving). Immersion in antiseptic solution is not recommended.
Autoclave at 15-pound pressure, at 121°C (250°F), for 15 minutes. The diluent dextrose may show some brown discoloration due to caramelization.
Protect solutions from light.