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Ivosidenib Dosage

Medically reviewed by Drugs.com. Last updated on Aug 22, 2024.

Applies to the following strengths: 250 mg

Usual Adult Dose for Acute Myeloid Leukemia

500 mg orally once a day
Duration of therapy: Until disease progression or unacceptable toxicity

Comments:


Uses:

Usual Adult Dose for Cholangiocarcinoma of biliary tract

500 mg orally once a day
Duration of therapy: Until disease progression or unacceptable toxicity

Use: For the treatment of patients with previously treated, locally advanced or metastatic cholangiocarcinoma with an IDH1 mutation as detected by a US FDA-approved test

Renal Dose Adjustments

Mild or moderate renal dysfunction (estimated GFR at least 30 mL/min/1.73 m2, Modification of Diet in Renal Disease [MDRD]):

Severe renal dysfunction (estimated GFR less than 30 mL/min/1.73 m2, MDRD): The risks and benefits should be considered before starting this drug.

Comment:

Liver Dose Adjustments

Mild or moderate liver dysfunction (Child-Pugh A or B):

Severe liver dysfunction (Child-Pugh C): The risks and benefits should be considered before starting this drug.

Comment:

Dose Adjustments

DOSAGE MODIFICATIONS FOR TOXICITIES:


Differentiation Syndrome:

Noninfectious Leukocytosis:

QTc Interval Greater Than 480 to 500 msec:

QTc Interval Greater Than 500 msec:

QTc Interval Prolongation with Signs/Symptoms of Life-Threatening Arrhythmia: This drug should be permanently discontinued.

Guillain-Barre Syndrome: This drug should be permanently discontinued.

Other Grade 3 Adverse Reactions:

DOSAGE MODIFICATIONS FOR USE WITH STRONG CYP450 3A4 INHIBITORS:

Precautions

US BOXED WARNING:


CONTRAINDICATIONS: None

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

The risks and benefits should be considered before starting this drug.

Comment:

Other Comments

Administration advice:


Storage requirement:

General:

Monitoring:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.