Hydroxyethyl Starch Dosage

Usual Adult Dose for Hypovolemia

Up to 50 mL/kg IV daily

• Duration of Therapy: Can be administered repetitively over several days.

Comments:

• The daily dose and rate of infusion depends on the patient's blood loss, on the maintenance or restoration of hemodynamic and on the hemodilution.

Use: For the treatment and prophylaxis of hypovolemia (this drug is not a substitute for red blood cells or coagulation factors in plasma)

Usual Pediatric Dose for Hypovolemia

Less than 2 years:
16 plus or minus 9 mL/kg IV daily (up to 50 mL/kg per day)

2 to 12 years:
36 plus or minus 11 mL/kg IV daily (up to 50 mL/kg per day)

Greater than 12 years:
Up to 50 mL/kg IV daily (up to 50 mL/kg per day)

Duration of Therapy: Can be administered repetitively over several days.

Comments: Dosage in children should be adapted to the individual patient colloid needs, considering the disease state, hemodynamic, and hydration status.

Use: For the treatment and prophylaxis of hypovolemia (this drug is not a substitute for red blood cells or coagulation factors in plasma)

Renal Dose Adjustments

• Dose adjustment(s) may be required; however, no specific guidelines have been suggested. Caution recommended.
• Avoid use in patients with preexisting renal dysfunction.
• Discontinue therapy at the first sign of renal injury.
• Monitor renal function in hospitalized patients for at least 90 days.

Liver Dose Adjustments

Mild to moderate hepatic impairment: Data not available
Severe hepatic impairment: Contraindicated

Precautions

US BOXED WARNINGS:
Mortality/Renal Replacement Therapy:

• In critically ill adult patients, including patients with sepsis, use of hydroxyethyl starch (HES) products increases the risk of mortality and renal replacement therapy.
• Do not use HES products in critically ill adult patients, including patients with sepsis.

CONTRAINDICATIONS:

• Hypersensitivity to the active component or any of the ingredients
• In critically ill adult patients, including patients with sepsis, due to increased risk of mortality and renal replacement therapy (RRT)
• Severe liver disease
• In volume overload
• Preexisting coagulation or bleeding disorders
• Renal failure with oliguria or anuria not related to hypovolemia
• Dialysis
• Severe hypernatremia
• Severe hyperchloremia
• Intracranial bleeding

Consult WARNINGS section for additional precautions.

Dialysis

Contraindicated

Other Comments

Administration advice:

• This drug is administered by IV infusion only.
• The daily dose and rate of infusion depend on the patient's blood loss, on the maintenance or restoration of hemodynamics and on the hemodilution (dilution effect).
• This drug can be administered repetitively over several days.
• The initial 10 to 20 mL should be infused slowly, keeping the patient under observation due to possible anaphylactoid reactions.

Storage requirements:

• Store at 15C to 25C (59F to 77F). Do not freeze.

Reconstitution/preparation techniques:

• Do not remove the container from its overwrap until immediately before use.
• Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
• Do not administer unless the solution is clear, free from particles and the container is undamaged.
• This drug should be used immediately after insertion of the administration set.
• Do not vent.
• If administered by pressure infusion, air should be withdrawn or expelled from the bag through the medication/administration port prior to infusion.
• Discontinue the infusion if an adverse reaction occurs.
• It is recommended that administration sets be changed at least once every 24 hours.
• For single use only. Discard unused portion.
• The manufacturer product information should be consulted.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer