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Hydroxyethyl Starch Dosage

Applies to the following strengths: 6%-NaCl 0.9%

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Hypovolemia

Up to 50 mL/kg IV daily
-Duration of Therapy: Can be administered repetitively over several days.

Comments:
-The daily dose and rate of infusion depends on the patient's blood loss, on the maintenance or restoration of hemodynamic and on the hemodilution.

Use: For the treatment and prophylaxis of hypovolemia (this drug is not a substitute for red blood cells or coagulation factors in plasma)

Usual Pediatric Dose for Hypovolemia

Less than 2 years:
16 plus or minus 9 mL/kg IV daily (up to 50 mL/kg per day)

2 to 12 years:
36 plus or minus 11 mL/kg IV daily (up to 50 mL/kg per day)

Greater than 12 years:
Up to 50 mL/kg IV daily (up to 50 mL/kg per day)

Duration of Therapy: Can be administered repetitively over several days.

Comments: Dosage in children should be adapted to the individual patient colloid needs, considering the disease state, hemodynamic, and hydration status.

Use: For the treatment and prophylaxis of hypovolemia (this drug is not a substitute for red blood cells or coagulation factors in plasma)

Renal Dose Adjustments

-Dose adjustment(s) may be required; however, no specific guidelines have been suggested. Caution recommended.
-Avoid use in patients with preexisting renal dysfunction.
-Discontinue therapy at the first sign of renal injury.
-Monitor renal function in hospitalized patients for at least 90 days.

Liver Dose Adjustments

Mild to moderate hepatic impairment: Data not available
Severe hepatic impairment: Contraindicated

Precautions

US BOXED WARNINGS:
Mortality/Renal Replacement Therapy:
-In critically ill adult patients, including patients with sepsis, use of hydroxyethyl starch (HES) products increases the risk of mortality and renal replacement therapy.
-Do not use HES products in critically ill adult patients, including patients with sepsis.

CONTRAINDICATIONS:
-Hypersensitivity to the active component or any of the ingredients
-In critically ill adult patients, including patients with sepsis, due to increased risk of mortality and renal replacement therapy (RRT)
-Severe liver disease
-In volume overload
-Preexisting coagulation or bleeding disorders
-Renal failure with oliguria or anuria not related to hypovolemia
-Dialysis
-Severe hypernatremia
-Severe hyperchloremia
-Intracranial bleeding

Consult WARNINGS section for additional precautions.

Dialysis

Contraindicated

Other Comments

Administration advice:
-This drug is administered by IV infusion only.
-The daily dose and rate of infusion depend on the patient's blood loss, on the maintenance or restoration of hemodynamics and on the hemodilution (dilution effect).
-This drug can be administered repetitively over several days.
-The initial 10 to 20 mL should be infused slowly, keeping the patient under observation due to possible anaphylactoid reactions.

Storage requirements:
-Store at 15C to 25C (59F to 77F). Do not freeze.

Reconstitution/preparation techniques:
-Do not remove the container from its overwrap until immediately before use.
-Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
-Do not administer unless the solution is clear, free from particles and the container is undamaged.
-This drug should be used immediately after insertion of the administration set.
-Do not vent.
-If administered by pressure infusion, air should be withdrawn or expelled from the bag through the medication/administration port prior to infusion.
-Discontinue the infusion if an adverse reaction occurs.
-It is recommended that administration sets be changed at least once every 24 hours.
-For single use only. Discard unused portion.
-The manufacturer product information should be consulted.

More about hydroxyethyl starch

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.