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Hydroxyethyl starch Side Effects

Medically reviewed by Last updated on Mar 18, 2022.

For the Consumer

Applies to hydroxyethyl starch: parenteral injection


  • Increased mortality and/or severe renal injury requiring renal replacement therapy reported in critically ill adults, including those with sepsis.1 104 Avoid use in such patients.1 104 (See Contraindications and also see Increased Mortality and Severe Renal Injury under Cautions.)

Side effects include:

Pruritus, increased serum amylase concentrations, hemodilution (resulting in decreased concentrations of coagulation factors, other plasma proteins, and hematocrit).

For Healthcare Professionals

Applies to hydroxyethyl starch: intravenous solution


Postmarketing reports: Hypotension/shock/circulatory collapse[Ref]


Common (1% to 10%): Decreased hematocrit

Rare (less than 0.1%): Coagulation disorders beyond dilution effects[Ref]


Rare (less than 0.1%): Anaphylactic/anaphylactoid/hypersensitivity reactions (e.g., hypersensitivity, mild influenza-like symptoms, bradycardia, tachycardia, bronchospasm, noncardiac pulmonary edema)[Ref]


Common (1% to 10%): Decreased plasma proteins[Ref]


Common (1% to 10%): Elevation of serum amylase, interference with the diagnosis of pancreatitis[Ref]

More about hydroxyethyl starch

Patient resources

Other brands


Professional resources

Related treatment guides


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Voluven (hydroxyethyl starch)." Hospira Inc (2013):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.