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Hydroxyethyl starch Side Effects

Medically reviewed by Last updated on Aug 21, 2023.

Applies to hydroxyethyl starch: intravenous solution.


  • This drug may raise the risk of severe kidney problems and death in people who are very ill or who have a severe blood infection. This drug must not be used in these people.

Serious side effects of Hydroxyethyl starch

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

Other side effects of Hydroxyethyl starch

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to hydroxyethyl starch: intravenous solution.


Postmarketing reports: Hypotension/shock/circulatory collapse[Ref]


Common (1% to 10%): Decreased hematocrit

Rare (less than 0.1%): Coagulation disorders beyond dilution effects[Ref]


Rare (less than 0.1%): Anaphylactic/anaphylactoid/hypersensitivity reactions (e.g., hypersensitivity, mild influenza-like symptoms, bradycardia, tachycardia, bronchospasm, noncardiac pulmonary edema)[Ref]


Common (1% to 10%): Decreased plasma proteins[Ref]


Common (1% to 10%): Elevation of serum amylase, interference with the diagnosis of pancreatitis[Ref]


1. Cerner Multum, Inc. Australian Product Information.

2. Product Information. Voluven (hydroxyethyl starch). Hospira Inc. 2013.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.