Medically reviewed by Drugs.com. Last updated on Jan 7, 2021.
Important Administration and Storage Instructions
- Avoid treatment with metoclopramide (all dosage forms and routes of administration) for longer than 12 weeks because of the increased risk of developing TD with longer-term use [see Warnings and Precautions (5.1)].
- One spray in one nostril administers the appropriate dose.
- Before administering the first dose from a bottle, prime the pump by pressing down on the finger flange and releasing 10 sprays in the air.
- Place the spray nozzle tip under one nostril and lean the head slightly forward so the tip of spray nozzle is aimed away from the septum and toward the back of the nose.
- Close the other nostril with the other index finger. Move spray pump upwards so the tip of the nozzle is in the nostril.
- To ensure a full dose, hold the bottle upright while pressing down firmly and completely on finger flange and release while inhaling slowly through the open nostril.
- Remove spray pump nozzle tip from nostril and exhale slowly through the mouth.
- Wipe the spray nozzle with a clean tissue.
Missed or Incomplete Doses
- If uncertain that the spray entered the nose, do not repeat the dose. Take the next dose at the scheduled time.
- If a dose is missed, take the next dose of GIMOTI at the regularly scheduled time. Do not make up for the missed dose or double the next dose.
Adults Less Than 65 Years of Age: The recommended dosage of GIMOTI for the treatment of acute and recurrent diabetic gastroparesis in adults is 1 spray (15 mg) in one nostril, 30 minutes before each meal and at bedtime (maximum of four times daily) for 2 to 8 weeks, depending on symptomatic response.
Adults 65 Years of Age and Older: Elderly patients may be more sensitive to the adverse effects of metoclopramide and require a lower starting dosage [see Warnings and Precautions (5.1)]. GIMOTI is not recommended in geriatric patients as initial therapy.
Geriatric patients receiving an alternative metoclopramide product at a stable dosage of 10 mg four times daily can be switched to GIMOTI 1 spray (15 mg) in one nostril, 30 minutes before each meal and at bedtime (maximum four times daily) for 2 to 8 weeks, depending on symptomatic response. Avoid treatment with metoclopramide (all dosage forms and routes of administration) for longer than 12 weeks [see Dosage and Administration (2.1)].
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