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Florbetaben F-18 Dosage

Usual Adult Dose for Positron Emission Tomography Imaging

300 MBq (8.1 mCi) as a slow single intravenous bolus (6 sec/mL) in a total volume of up to 10 mL
Maximum dose: 300 mcg mass

Comments: Acquire PET images over 15 to 20 minutes starting 45 to 130 minutes after florbetaben injection.

Use: Positron Emission Tomography (PET) imaging of the brain to estimate beta-amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer's Disease (AD) and other causes of cognitive decline.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

This drug is not indicated for use in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Florbetaben is a radioactive drug and should be handled with appropriate safety measures to minimize radiation exposure during administration.
-Use waterproof gloves and effective shielding, including lead-glass syringe shields when handling and administering this drug.
-This drug should only be used by or under the control of qualified physicians with training and experience in the safe use and handling of radioactive materials, and who is licensed to the use of radiopharmaceuticals.

Application techniques:
-Inspect the radiopharmaceutical dose solution prior to administration and do not use it if it contains particulate matter.
-Use aseptic technique and radiation shielding to withdraw and administer florbetaben solution.
-Measure the activity of this drug with a dose calibrator immediately prior to injection.
-Do not dilute florbetaben.
-The injection must be intravenous in order to avoid irradiation as a result of local extravasation, as well as imaging artifacts. Verify patency of the indwelling catheter by a saline test injection prior to administration of this drug.
-An injection (6 sec/mL) into a large vein in the arm is recommended, followed by a saline flush of approximately 10 mL.
-Dispose unused product in compliance with applicable regulations.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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