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Applies to the following strength(s): 85 mg ; 150 mg
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for HIV Infection
With once-daily atazanavir/ritonavir or twice-daily lopinavir-ritonavir: 85 mg orally once a day with food
With twice-daily darunavir/ritonavir, fosamprenavir/ritonavir, or tipranavir/ritonavir: 150 mg orally once a day with food
-The manufacturer product information should be consulted for the recommended dosing regimen for atazanavir/ritonavir, lopinavir-ritonavir, darunavir/ritonavir, fosamprenavir/ritonavir, or tipranavir/ritonavir; this drug should not be used with other dose regimens or HIV-1 protease inhibitors.
-This drug should not be used with cobicistat and protease inhibitors.
Use: In combination with a ritonavir-boosted HIV protease inhibitor and at least 1 other antiretroviral drug, for the treatment of HIV-1 infection in antiretroviral therapy-experienced patients
Renal Dose Adjustments
No adjustment recommended.
Liver Dose Adjustments
Mild or moderate liver dysfunction (Child-Pugh A or B): No adjustment recommended.
Severe liver dysfunction (Child-Pugh C): Not recommended.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available
Comments: This drug is highly protein-bound; significant removal via hemodialysis or peritoneal dialysis is not likely.
-Administer with food.
-Use in combination with a ritonavir-boosted protease inhibitor and at least 1 other antiretroviral drug.
-Administer antacids at least 2 hours before or after this drug.
-Store below 30C (86F) in original bottle
-Treatment history and resistance testing (if available) should guide the use of elvitegravir-containing regimens.
-The manufacturer product information for the coadministered protease inhibitor, ritonavir, and other coadministered antiretroviral drugs should be consulted.