Bretylium Dosage
Applies to the following strengths: 50 mg/mL; 200 mg/100 mL-5%; 400 mg/100 mL-5%
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Ventricular Fibrillation
Initial dose: 5 mg/kg undiluted IV once.
If V Fib persists: 10 mg/kg undiluted IV and repeat as necessary.
Maintenance: 1 to 2 mg/min by continuous IV infusion or
5 to 10 mg/kg diluted IV over 8 minutes every 6 hours.
Usual Adult Dose for Ventricular Tachycardia
Initial dose: 5 to 10 mg/kg diluted IV over > 8 minutes.
If arrhythmia persists: Give subsequent doses at 1 to 2 hour intervals
Maintenance: 1 to 2 mg/min by continuous IV infusion or
5 to 10 mg/kg diluted IV over 8 minutes every 6 hours.
IM: 5 to 10 mg/kg undiluted.
If the arrhythmia persists: Give subsequent doses at 1 to 2 hour intervals.
Maintenance dose: The same dose every 6 to 8 hours.
Usual Pediatric Dose for Ventricular Fibrillation
> 1 year: Initial dose: 5 mg/kg/dose IV.
If V Fib persists: 10 mg/kg at 15 to 30 minute intervals to a maximum dose of 30 mg/kg.
Maintenance dose: 5 to 10 mg/kg IV every 6 hours.
Usual Pediatric Dose for Ventricular Tachycardia
> 1 year: 5 to 10 mg/kg IV every 6 hours.
Renal Dose Adjustments
CrCl < 10 mL/min: A reduction in dose to 25% is suggested.
CrCl 10-50 mL/min: A reduction in dose to 25% to 50% is suggested.
Liver Dose Adjustments
Data not available
Dialysis
Bretylium is not dialyzable (0%-5%) via hemo- or peritoneal dialysis. Supplemental doses are not needed.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about bretylium
- Side Effects
- During Pregnancy or Breastfeeding
- Drug Interactions
- Pricing & Coupons
- Drug class: group III antiarrhythmics
