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Vorasidenib Disease Interactions

There are 3 disease interactions with vorasidenib.

Moderate

Vorasidenib (applies to vorasidenib) liver dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

The pharmacokinetics and safety of vorasidenib have not been studied in patients with severe liver dysfunction (Child-Pugh C); these patients should be monitored for increased adverse reactions and the dosage should be modified for adverse reactions as recommended in the manufacturer product information. No dosage adjustment is recommended for patients with mild or moderate liver dysfunction (Child-Pugh A or B).

Moderate

Vorasidenib (applies to vorasidenib) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

The pharmacokinetics and safety of vorasidenib have not been studied in patients with CrCl up to 40 mL/min or renal dysfunction requiring dialysis; these patients should be monitored for increased adverse reactions and the dosage should be modified for adverse reactions as recommended in the manufacturer product information. No dosage adjustment is recommended for patients with CrCl greater than 40 mL/min.

Moderate

Vorasidenib (applies to vorasidenib) smoking

Moderate Potential Hazard, Moderate plausibility.

Tobacco smoking may decrease vorasidenib plasma levels, which may reduce its antitumor activity. Patients and caregivers should be advised to inform their health care provider if they currently smoke tobacco.

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Vorasidenib drug interactions

There are 436 drug interactions with vorasidenib.

Vorasidenib alcohol/food interactions

There is 1 alcohol/food interaction with vorasidenib.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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