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Vasopressin Disease Interactions

There are 4 disease interactions with vasopressin.

Major

Vasopressin (applies to vasopressin) nephritis

Major Potential Hazard, Moderate plausibility. Applicable conditions: Glomerulonephritis

Chronic nephritis with nitrogen retention contraindicates the use of vasopressin until reasonable nitrogen blood levels have been attained.

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Major

Vasopressin (applies to vasopressin) renal impairment

Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Vasopressin is contraindicated in patients with chronic nephritis with nitrogen retention. This until reasonable nitrogen blood levels have been attained.

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Major

Vasopressin (applies to vasopressin) vascular disease

Major Potential Hazard, High plausibility. Applicable conditions: Cerebral Vascular Disorder, Peripheral Arterial Disease, Ischemic Heart Disease

Vasopressin should not be used in patients with vascular disease, especially disease of the coronary arteries, except with extreme caution. In such patients, even small doses may precipitate anginal pain, and large doses may cause myocardial infarction. If a decision is made to use the drug, ECG monitoring should be performed periodically during therapy.

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Major

Vasopressin/desmopressin (applies to vasopressin) fluid overload/hyponatremia

Major Potential Hazard, High plausibility. Applicable conditions: Congestive Heart Failure, Seizures, Asthma, Fluid Retention, Migraine

Water intoxication and hyponatremia may occur during therapy with vasopressin or desmopressin due to their antidiuretic action. Patients are most likely to experience this problem if their fluid intake is excessive or if they do not require antidiuresis, such as when they are administered these agents for their hemostatic effects. Fluid intake should be adjusted carefully to avoid overhydration, particularly in children, elderly, and patients with conditions that may be exacerbated by fluid retention, including epilepsy, migraine, asthma, and heart failure. Patients should be monitored for signs of water intoxication (e.g., listlessness, drowsiness, and headaches), which may rarely progress to seizures and coma. The use of desmopressin is contraindicated in patients with hyponatremia or a history of hyponatremia.

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Vasopressin drug interactions

There are 288 drug interactions with vasopressin.

Vasopressin alcohol/food interactions

There is 1 alcohol/food interaction with vasopressin.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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