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Pitressin (vasopressin) Disease Interactions

There is 1 disease interaction with Pitressin (vasopressin):


Vasopressin (Includes Pitressin) ↔ Vascular Disease

Severe Potential Hazard, High plausibility

Applies to: Cerebral Vascular Disorder, Peripheral Arterial Disease, Ischemic Heart Disease

Vasopressin should not be used in patients with vascular disease, especially disease of the coronary arteries, except with extreme caution. In such patients, even small doses may precipitate anginal pain, and large doses may cause myocardial infarction. If a decision is made to use the drug, ECG monitoring should be performed periodically during therapy.


  1. Khokhar AM, Slater JD, Ma J, Ramage CM "The cardiovascular effect of vasopressin in relation to its plasma concentration in man and its relevance to high blood pressure." Clin Endocrinol (Oxf) 13 (1980): 259-66
  2. Beller BM, Trevino A, Urban E "Pitressin-induced myocardial injury and depression in a young woman." Am J Med 51 (1971): 675-9
  3. Brearley S, Hawker PC, Dykes PW, Keighley MR "A lethal complication of peripheral vein vasopressin infusion." Hepatogastroenterology 32 (1985): 224-5
  4. Kelly KJ, Stang JM, Mekhjian HS "Vasopressin provocation of ventricular dysrhythmia." Ann Intern Med 92 (1980): 205-6
  5. Wormser GP, Kornblee LV, Gottfried EB "Cutaneous necrosis following peripheral intravenous vasopressin therapy." Cutis 29 (1982): 249-52
  6. "Product Information. Pitressin (vasopressin)." Parke-Davis, Morris Plains, NJ.
  7. Jacoby AG, Wiegman MV "Cardiovascular complications of intravenous vasopressin therapy." Focus Crit Care 17 (1990): 63-6
  8. Lambert M, de Peyer R, Muller AF "Reversible ischemic colitis after intravenous vasopressin therapy." JAMA 247 (1982): 666-7
  9. Butow KW, de Witt TW, Jacobs FJ "Ornithine-vasopressin gangrene and reconstruction of the upper lip. Case report." J Craniomaxillofac Surg 17 (1989): 88-91
  10. Colombani P "Upper extremity gangrene secondary to superior mesenteric artery infusion of vasopressin." Dig Dis Sci 27 (1982): 367-9
  11. Greenwald RA, Rheingold OJ, Chiprut RO, Rogers AI "Local gangrene: a complication of peripheral Pitressin therapy for bleeding esophageal varices." Gastroenterology 74 (1978): 744-6
View all 11 references

Pitressin (vasopressin) drug Interactions

There are 317 drug interactions with Pitressin (vasopressin)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.