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Grafapex Disease Interactions

There are 2 disease interactions with Grafapex (treosulfan).

Moderate

Treosulfan (applies to Grafapex) liver and renal dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Treosulfan has not been studied in patients with moderate or severe liver and renal dysfunction.

Moderate

Treosulfan (applies to Grafapex) seizures

Moderate Potential Hazard, Moderate plausibility.

There have been reports of seizures in patients following treatment with treosulfan. Patients should be monitored for signs of neurological adverse reactions, and clonazepam prophylaxis may be considered for patients at higher risk for seizures, including infants.

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Grafapex drug interactions

There are 523 drug interactions with Grafapex (treosulfan).


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.