Grafapex Disease Interactions
There are 2 disease interactions with Grafapex (treosulfan).
Treosulfan (applies to Grafapex) liver and renal dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Treosulfan has not been studied in patients with moderate or severe liver and renal dysfunction.
Treosulfan (applies to Grafapex) seizures
Moderate Potential Hazard, Moderate plausibility.
There have been reports of seizures in patients following treatment with treosulfan. Patients should be monitored for signs of neurological adverse reactions, and clonazepam prophylaxis may be considered for patients at higher risk for seizures, including infants.
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Grafapex drug interactions
There are 528 drug interactions with Grafapex (treosulfan).
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- Drug class: alkylating agents
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
