Tolazoline Disease Interactions
There are 4 disease interactions with tolazoline.
Tolazoline (applies to tolazoline) vascular dysfunction
Major Potential Hazard, High plausibility. Applicable conditions: Cerebral Vascular Disorder, Ischemic Heart Disease
The use of tolazoline is contraindicated in patients with coronary artery disease or insufficiency or following a cerebrovascular accident. Hypotension due to decreased peripheral vascular resistance results from direct relaxation of vascular smooth muscle and alpha adrenergic blockade. Heart rate and cardiac output are increased.
Tolazoline (applies to tolazoline) acid-base balance
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Acidosis
The therapeutic efficacy of tolazoline in reducing persistent vasoconstriction and pulmonary hypertension may be pH dependent. Acidosis may decrease the efficacy of tolazoline.
Tolazoline (applies to tolazoline) histamine release
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Peptic Ulcer, Alkalosis, Gastrointestinal Hemorrhage
The histamine-releasing properties of tolazoline can stimulate gastric secretion resulting in hypochloremic alkalosis, stress ulcers, and GI bleeding. Therapy with tolazoline should be administered cautiously in patients with GI disorders such as gastritis, enteritis, or peptic ulcer disease.
Tolazoline (applies to tolazoline) renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
Tolazoline is primarily eliminated by the kidney as unchanged drug. The serum concentration of tolazoline can be increased in patients with renal impairment. Therapy with tolazoline should be administered cautiously in patients with compromised renal function. Clinical monitoring of vital signs, blood gases, and renal function is recommended.
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Tolazoline drug interactions
There are 106 drug interactions with tolazoline.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
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