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Succimer Disease Interactions

There are 4 disease interactions with succimer:

Moderate

Succimer (applies to succimer) dehydration

Moderate Potential Hazard, High plausibility.

Succimer is primarily eliminated by the kidney. Therapy with succimer should be administered after dehydration is corrected and urine output sufficient for the elimination of succimer.

References

  1. "Product Information. Chemet (succimer)." McNeil Pharmaceutical, Raritan, NJ.
Moderate

Succimer (applies to succimer) liver disease

Moderate Potential Hazard, High plausibility.

Succimer undergoes extensive metabolism by the liver. Therapy with succimer should be administered cautiously in patients with liver disease.

References

  1. "Product Information. Chemet (succimer)." McNeil Pharmaceutical, Raritan, NJ.
Moderate

Succimer (applies to succimer) neutropenia

Moderate Potential Hazard, Moderate plausibility.

Mild to moderate neutropenia has been observed in some patients receiving succimer. A complete blood count with white blood cell differential and direct platelet counts should be obtained prior to and weekly during treatment. Therapy should either be withheld or discontinued if the absolute neutrophil count (ANC) is below 1200/mcL and the patient followed closely to document recovery of the ANC to above 1500/mcL or to the patient's baseline neutrophil count. There is limited experience with reexposure in patients who have developed neutropenia. Therefore, such patients should be rechallenged only if the benefit of therapy clearly outweighs the potential risk of another episode of neutropenia and then only with careful patient monitoring.

Moderate

Succimer (applies to succimer) renal dysfunction

Moderate Potential Hazard, High plausibility.

Succimer is primarily eliminated by the kidney complexed with a heavy metal (lead, arsenic, mercury). Therapy with succimer should be administered cautiously in patients with renal impairment. Succimer should be discontinued if acute renal failure develops. Clinical monitoring of renal function is necessary. However, succimer has been used with some success in combination with extracorporeal regional complexing hemodialysis in patients with renal failure.

References

  1. "Product Information. Chemet (succimer)." McNeil Pharmaceutical, Raritan, NJ.

Succimer drug interactions

There is 1 drug interaction with succimer

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.