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Nithiodote (sodium nitrite / sodium thiosulfate) Disease Interactions

There are 3 disease interactions with Nithiodote (sodium nitrite / sodium thiosulfate):

Major

Sodium nitrite (applies to Nithiodote) methemoglobinemia/hypotension

Major Potential Hazard, High plausibility. Applicable conditions: G-6-PD Deficiency, Anemia, Pulmonary Impairment

Sodium nitrite causes hypotension and methemoglobin formation, which diminishes oxygen carrying capacity. Hypotension and methemoglobin formation can occur concurrently or separately. Sodium nitrite should be used to treat acute life-threatening cyanide poisoning but be used with caution in patients where the diagnosis of cyanide poisoning is uncertain. Patients should be closely monitored to ensure adequate perfusion and oxygenation during treatment with sodium nitrite. Alternative therapeutic approaches should be considered in patients known to have diminished oxygen or cardiovascular reserve (e.g., smoke inhalation victims, preexisting anemia, cardiac or respiratory compromise), and those at higher risk of developing methemoglobinemia (e.g., congenital methemoglobin reductase deficiency) as they are at greater risk for potentially life-threatening adverse events related to the use of sodium nitrite.

References

  1. "Product Information. Cyanide Antidote Kit (sodium nitrite)." Lilly, Eli and Company, Indianapolis, IN.
Moderate

Sodium nitrite (applies to Nithiodote) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Sodium nitrite is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.

Moderate

Sodium thiosulfate (applies to Nithiodote) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Sodium thiosulfate is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Care should be exercised when using this agent in patients with impaired renal function. Renal function should be monitored regularly in patients receiving therapy.

Nithiodote (sodium nitrite / sodium thiosulfate) drug interactions

There are 161 drug interactions with Nithiodote (sodium nitrite / sodium thiosulfate)

More about Nithiodote (sodium nitrite / sodium thiosulfate)

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.