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Rilpivirine Disease Interactions

There are 3 disease interactions with rilpivirine:

Moderate

Rilpivirine (Includes Rilpivirine) ↔ Depression

Moderate Potential Hazard, Moderate plausibility

Applies to: Depression, Psychosis

Depressive symptoms including suicide ideation and suicide attempts have been reported with the use of rilpivirine. Patients should be monitored for the appearance of these symptoms and should seek medical evaluation immediately if severe depressive symptoms occur. Caution should be used in patients with a history of depression or other psychiatric conditions.

Moderate

Rilpivirine (Includes Rilpivirine) ↔ Liver Impairment

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease, Infectious Hepatitis

Hepatic adverse events have been reported in patients taking rilpivirine. Patients with underlying hepatitis B or C may be at increased risk for worsening or development of transaminase elevations. A few cases of hepatic toxicity have been reported in patients with no pre-existing hepatic conditions or risk factors. Appropriate laboratory testing prior to treatment and monitoring for hepatotoxicity is recommended, especially in patients with hepatitis B or C or patients with marked elevations in transaminases. The use of rilpivirine has not been studied in patients with severe hepatic impairment (Child Pugh Class C).

Moderate

Rilpivirine (Includes Rilpivirine) ↔ Renal Impairment

Moderate Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

Rilpivirine should be used with caution in patients with severe renal impairment or end-stage renal disease, as drug concentrations can be increased due to alteration of drug absorption, distribution, and metabolism secondary to renal dysfunction. No dose adjustment is required in patients with mild or moderate renal impairment.

rilpivirine drug Interactions

There are 378 drug interactions with rilpivirine

rilpivirine alcohol/food Interactions

There is 1 alcohol/food interaction with rilpivirine

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2017 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

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