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Rilpivirine Disease Interactions

There are 3 disease interactions with rilpivirine:


Rilpivirine (Includes rilpivirine) ↔ depression

Moderate Potential Hazard, Moderate plausibility. Applies to: Depression, Psychosis

Depressive symptoms including suicide ideation and suicide attempts have been reported with the use of rilpivirine. Patients should be monitored for the appearance of these symptoms and should seek medical evaluation immediately if severe depressive symptoms occur. Caution should be used in patients with a history of depression or other psychiatric conditions.


Rilpivirine (Includes rilpivirine) ↔ liver impairment

Moderate Potential Hazard, Moderate plausibility. Applies to: Infectious Hepatitis

Hepatic adverse events have been reported in patients taking rilpivirine. Patients with underlying hepatitis B or C may be at increased risk for worsening or development of transaminase elevations. A few cases of hepatic toxicity have been reported in patients with no pre-existing hepatic conditions or risk factors. Appropriate laboratory testing prior to treatment and monitoring for hepatotoxicity is recommended, especially in patients with hepatitis B or C or patients with marked elevations in transaminases. The use of rilpivirine has not been studied in patients with severe hepatic impairment (Child Pugh Class C).


Rilpivirine (Includes rilpivirine) ↔ renal impairment

Moderate Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction

Rilpivirine should be used with caution in patients with severe renal impairment or end-stage renal disease, as drug concentrations can be increased due to alteration of drug absorption, distribution, and metabolism secondary to renal dysfunction. No dose adjustment is required in patients with mild or moderate renal impairment.

Rilpivirine drug interactions

There are 410 drug interactions with rilpivirine

Rilpivirine alcohol/food interactions

There is 1 alcohol/food interaction with rilpivirine

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.