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Rabies immune globulin, human Disease Interactions

There are 2 disease interactions with rabies immune globulin, human.

Major

Rabies (applies to rabies immune globulin, human) antibody response

Major Potential Hazard, High plausibility. Applicable conditions: Immunodeficiency

Patients with primary or acquired deficient/impaired immune response (immunosuppressive therapy, genetic, splenic dysfunction, immunodeficiency disorders) may have reduced antibody response to immunizations. Deferral of immunosuppressive therapy may be considered pending completion of post-exposure therapy unless essential for treatment of other conditions.

References

  1. (2001) "Product Information. Bayrab (rabies immune globulin, human)." Bayer
Major

Vaccines (applies to rabies immune globulin, human) IM injection

Major Potential Hazard, Moderate plausibility. Applicable conditions: Thrombocytopenia, Thrombocytopathy, Coagulation Defect

In patients with thrombocytopenia or coagulation disorders, intramuscular injections may produce bleeding and hematomas. Patients with a platelet count less than 50,000/mm3 are at an increased risk. Caution is advised if the vaccine (e.g., plague vaccine, hepatitis A and B vaccines, and aluminum-adsorbed DTaP, DTP, DT, or Td) must be administered intramuscularly. The risk of bleeding may be minimized by vaccination immediately after the administration of replacement factor, use of a 23-gauge (or smaller) needle, and immediate application of direct pressure to the vaccination site for at least 2 minutes.

References

  1. (2001) "Product Information. Plague Vaccine (plague vaccine)." Greer Laboratories Inc
  2. American Academy of Pediatrics. Committee on Infectious Diseases; Peter G, ed. (1997) "Red BooK: Report of the Committee on Infectious Diseases." Grove Village, IL: American Academy of Pediatrics
  3. "Product Information. Cholera Vaccine (cholera vaccine)." Wyeth-Ayerst Laboratories
  4. "Product Information. Havrix (HepA) (hepatitis A adult vaccine)." SmithKline Beecham
  5. (2022) "Product Information. Engerix-B (HepB) (hepatitis B adult vaccine)." Apothecon Inc
  6. (2005) "Product Information. Menactra (meningococcal conjugate vaccine)." sanofi pasteur
  7. (2022) "Product Information. ActHIB (Hib) (haemophilus b conjugate (PRP-T) vaccine)." sanofi pasteur
  8. (2010) "Product Information. Imogam Rabies-HT (rabies immune globulin, human)." sanofi pasteur
  9. (2015) "Product Information. Hyperrab S/D (rabies immune globulin, human)." Grifols Therapeutics
  10. (2022) "Product Information. Bexsero (meningococcal group B vaccine)." Novartis Vaccines & Diagnostics Inc
View all 10 references

Rabies immune globulin, human drug interactions

There are 25 drug interactions with rabies immune globulin, human.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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