Radiogardase (prussian blue) Disease Interactions
There are 3 disease interactions with Radiogardase (prussian blue):
Prussian blue (Includes Radiogardase) ↔ constipation
Moderate Potential Hazard, Moderate plausibility. Applies to: Gastrointestinal Obstruction, Constipation
Prussian blue insoluble is not absorbed through the intact gastrointestinal wall and its clearance depends on the gastrointestinal tract transit time. Prussian blue can decrease gastrointestinal motility and slow the transit time of the agent in the gastrointestinal tract and increase the radiation absorbed. Also, the use of prussian blue can cause constipation. Care is recommended in patients with disorders associated with decreased gastrointestinal motility as these patients are at higher risk and should be carefully monitored.
Prussian blue (Includes Radiogardase) ↔ electrolyte abnormalities
Moderate Potential Hazard, Moderate plausibility. Applies to: Arrhythmias, Electrolyte Abnormalities
The use of prussian blue may decrease electrolytes found in the gastrointestinal tract. Hypokalemia has been reported with the use of prussian blue, and this might be more pronounced in patients with preexisting cardiac arrhythmias or electrolyte imbalances. It is recommended to closely monitor these patient's serum electrolytes levels during therapy with this agent.
Prussian blue (Includes Radiogardase) ↔ liver dysfunction
Moderate Potential Hazard, Moderate plausibility. Applies to: Liver Disease
Prussian blue insoluble binds cesium and thallium isotopes in the gastrointestinal tract after these isotopes are ingested or excreted in the bile by the liver. Prussian blue does not rely on hepatic metabolism. Its clearance from the body depends on the gastrointestinal tract transit time. Prussian blue may be less effective in patients with liver disease due to decreased excretion of cesium and thallium in the bile. Care should be exercised when using this agent in patients with hepatic impairment.
Radiogardase (prussian blue) alcohol/food interactions
There is 1 alcohol/food interaction with Radiogardase (prussian blue)
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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